Evaluation of a prognostic score for the identification of patients with poor prognosis in cerebral venous thrombosis : a multicentric prospective cohort study protocol

Solés Gimbernat, Aniol
Background: Cerebral venous thrombosis (CVT) is a disease with a low incidence but higher incidence rates among young adults, pregnant women and new-bourns. It generally has a good prognosis, but a significant number of deaths and important sequels, due to the limited management of patients who don't respond to anticoagulants, the standard treatment. Endovascular treatments have shown promising results in these patients, but are nowadays only performed in very deteriorated patients with low chance of survival. An early identification of patients with cerebral venous thrombosis with high risk of deterioration would allow for a better adjustment of the clinical following and monitoring, or even performing earlier endovascular treatments, improving the overall prognosis of the disease. Objectives: The aim of this study is to derive and validate a prognostic score to quickly recognise these patients. Secondarily, the study will investigate if the prognostic factors vary in pregnant women or new-bourns population subgroups. Methods: A national multicentric prospective cohort study will be performed with a sample formed by 983 men and 667 women with cerebral venous thrombosis. Clinical, imaging and laboratory variables will be collected from each patient, and a logistic regression analysis will be used to develop predictive model for death or disability that will be submitted to validation analysis ​
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