Background: Cerebral venous thrombosis (CVT) is a disease with a low incidence but
higher incidence rates among young adults, pregnant women and new-bourns. It
generally has a good prognosis, but a significant number of deaths and important
sequels, due to the limited management of patients who don't respond to
anticoagulants, the standard treatment. Endovascular treatments have shown
promising results in these patients, but are nowadays only performed in very
deteriorated patients with low chance of survival. An early identification of patients with
cerebral venous thrombosis with high risk of deterioration would allow for a better
adjustment of the clinical following and monitoring, or even performing earlier
endovascular treatments, improving the overall prognosis of the disease.
Objectives: The aim of this study is to derive and validate a prognostic score to quickly
recognise these patients. Secondarily, the study will investigate if the prognostic factors
vary in pregnant women or new-bourns population subgroups.
Methods: A national multicentric prospective cohort study will be performed with a
sample formed by 983 men and 667 women with cerebral venous thrombosis. Clinical,
imaging and laboratory variables will be collected from each patient, and a logistic
regression analysis will be used to develop predictive model for death or disability that
will be submitted to validation analysis
DUGiDocs