Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
dc.contributor.author
dc.date.accessioned
2020-06-08T09:54:00Z
dc.date.available
2020-06-08T09:54:00Z
dc.date.issued
2020-04-30
dc.identifier.issn
0167-6806
dc.identifier.uri
dc.description.abstract
Purpose
The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score.
Methods
The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors.
Results
Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively.
Conclusion
Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased
dc.description.sponsorship
Biological samples were stored at the biobanks supported
by Instituto de Salud Carlos III- FEDER: Parc de Salut MAR Biobank
(MARBiobanc) (RD09/0076/00036), ‘Biobanco La Fe’ (RD 09
0076/00021) and FISABIO Biobank (RD09 0076/00058), as well as
at the Public Health Laboratory of Gipuzkoa, the Basque Biobank, the
ICOBIOBANC (sponsored by the Catalan Institute of Oncology), the
IUOPA Biobank of the University of Oviedo and the ISCIII Biobank.
SNP genotyping services were provided by the Spanish ‘Centro
Nacional de Genotipado’ (CEGEN-ISCIII). We thank all the subjects
who participated in the study and all MCC-Spain collaborators. This
work was supported by the ‘Acción Transversal del Cancer’, approved
by the Spanish Ministry Council on the 11th October 2007, by the
Instituto de Salud Carlos III, co-founded by FEDER funds – ‘a way to
build Europe’ (grants PI08/1770, PI08/0533, PI08/1359, PI09/00773,
PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488,
PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219,
PI14/00613 and PI15/00069). Support was also provided by the Fundación Marqués de Valdecilla (grant API 10/09); the Junta de Castilla
y León (grant LE22A10-2); the Consejería de Salud of the Junta de
Andalucía (2009-S0143); the Conselleria de Sanitat of the Generalitat Valenciana (grant AP 061/10); the Recercaixa (grant 2010ACUP
00310); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commission
grants FOOD-CT-2006–036224-HIWATE; the Spanish Association
Against Cancer (AECC) Scientifc Foundation; the Catalan Government DURSI (grant 2014SGR647); the Fundación Caja de Ahorros de
Asturias; the University of Oviedo; Societat Catalana de Digestologia;
and COST action BM1206 Eucolongene
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1007/s10549-020-05600-x
dc.relation.ispartof
Breast Cancer Research and Treatment, 2020, vol. 181, p. 667-678
dc.relation.ispartofseries
Articles publicats (D-I)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.subject
dc.title
Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
031412
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1573-7217