Metoprolol and metoprolol acid degradation in UV/H2O2 treated wastewaters: An integrated screening approach for the identification of hazardous transformation products
dc.contributor.author
dc.date.accessioned
2019-07-12T06:50:36Z
dc.date.available
2019-07-12T06:50:36Z
dc.date.issued
2019-07-06
dc.identifier.issn
0304-3894
dc.identifier.uri
dc.description.abstract
Advancements on analytical strategies to determine the chemicals present in treated wastewater are necessary to clearly link their occurrence with the ecotoxicity of such effluents. This study describes the development of an integrated screening approach to determine the highest number of pharmaceutical transformation products (TPs) in a single run. The identification of TPs was based on the comparison of detected features with literature sources, compound prediction tools, in-house libraries and reference standards using high resolution mass spectrometry (HRMS). This integrated approach allowed a better estimation (in silico) of the ecotoxicological contribution of the individual TPs identified. As a proof of concept, this methodology was applied for identification of the TPs generated from metoprolol and its main human metabolite (metoprolol acid) in pure water, hospital wastewater and industrial wastewater treated by UV/H2O2. Twenty-four TPs with potential ecotoxicological implications were identified and their presence was pinpointed as a function of the treated wastewater. An integrated screening approach has been developed using four different screening methodologies in the same run. Additionally, the metabolite MTPA has been considered as a target pollutant in UV/H2O2 experiments
dc.description.sponsorship
This work has been funded by the Spanish Ministry of Economy and Competitiveness (projects CTM 2013 48545-C2-1-R and CTM2017-85385-C2-1-R) and partly supported by the Generalitat de Catalunya (Consolidated Research Groups 2017-SGR-14, 2017-SGR-1404, 2017-SGR-1124, 2017-SGR-1318 and 2017-SGR-1016). S.R.M and R.G.O acknowledge the “Redes de Excelencia 2015” program (CTM2015-71054-REDT). S.R.M and G.B. acknowledge the Ramon y Cajal research fellowships (RYC-2014- 16707 and RYC-2014-16754) from the Spanish Ministry of Economy and Competitiveness. A.J.G. acknowledges the predoctoral grant from AGAUR (2018FI_B1_00212). R.G.O thanks to “Obra Social La Caixa” for receiving funding to carry out this research through the Intensification Research Fellowship 2017-URL-IR2Q-023
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
MINECO/PN 2013-2016/CTM2013-48545-C2-1-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTM2017-85385-C2-1-R/ES/ECONOMIA CIRCULAR PARA FACILITAR LA REUTILIZACION DE AGUA URBANA EN UNA CIUDAD TURISTICA: GESTION CENTRALIZADA O DESCENTRALIZADA?/
dc.relation.isformatof
Versió postprint del document publicat a: https://doi.org/10.1016/j.jhazmat.2019.120851
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© Journal of Hazardous Materials Available, 2019, art.núm.120851
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Articles publicats (ICRA)
dc.rights
Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
dc.rights.uri
dc.subject
dc.title
Metoprolol and metoprolol acid degradation in UV/H2O2 treated wastewaters: An integrated screening approach for the identification of hazardous transformation products
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2021-07-06
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
1873-3336