Valoració del filtrat glomerulal estimat (FGe) i la creatinina sèrica en la insuficiència renal crònica

Abstract

Chronic kidney disease (CKD) is currently a public health problem worldwide. CKD is a silence disease that does not cause any pain, which is why it is very difficult to be diagnosed by the patient thus early detection of chronic kidney disease is an important key to avoid further progression. CKD is defined as a progressive, permanent and irreversible loss of the glomerular filtration rate over a variable time, sometimes even years, expressed by a reduced clearance of creatinine < 60 ml/min/1,73m2. Glomerular filtration is the best index of measurement of renal function because it provides a measure of the kidney’s filtering capacity and perfectly reflects the functioning renal mass. However, the measurement of glomerular filtration is difficult to carry out and so alternatives have been developed. Among the methods that allow us to estimate glomerular filtration there are serum creatinine and estimation using equations such as CKD-EPI. In this work parameters such as "serum creatinine" and "estimation of the glomerular filtration CKD - EPI" have been studied as a measure of chronic kidney disease for the population of different parts of Catalonia between the ages of 15 to 104 years. It has been found that the relationship between these two parameters is illustrated in a hyperbola curve. This implies the need for abrupt reduction in glomerular filtration for an increase of creatinine above universally established reference values. On the other hand, serum creatinine is a parameter with a high individual influence and this is why it should be analysed from the change reference value. This new method would allow detecting cases of chronic renal insufficiency in patients where serum creatinine values are still within the universal reference ranges. Finally, the distribution of CKD in the population studied according to age and sex has been studied. It has been shown that age is a susceptibility factor in the progression of CKD, that both sexes have a very similar distribution for the affectation of this disease and that the majority of the population is in the third stage of the classification of the CKD