This paper presents an experimental study of the translaminar fracture toughness under tensile and compressive loads of interply hybrid polymer-matrix composite laminates. The studied laminates were obtained by combining two of three different reinforcements: woven carbon fabric, woven glass fabric and unidirectional carbon tape, manufactured using the Resin Transfer Molding (RTM) process. The resulting in-plane quasi-isotropic laminates were generated by changing each material location along the thickness