{ "dc.contributor.author": "Martí Lluch, Ruth" , "dc.contributor.author": "Parramon, Dídac" , "dc.contributor.author": "García Ortiz, Luís" , "dc.contributor.author": "Rigo, Fernando" , "dc.contributor.author": "Gómez Marcos, Manuel A." , "dc.contributor.author": "Sempere, Irene" , "dc.contributor.author": "García Regalado, Natividad" , "dc.contributor.author": "Recio Rodriguez, Jose I." , "dc.contributor.author": "Agudo Conde, Cristina" , "dc.contributor.author": "Feuerbach, Natalia" , "dc.contributor.author": "García Gil, María del Mar" , "dc.contributor.author": "Ponjoan Thäns, Anna" , "dc.contributor.author": "Quesada Sabaté, Miquel" , "dc.contributor.author": "Ramos Blanes, Rafel" , "dc.date.accessioned": "2013-02-04T08:52:27Z" , "dc.date.available": "2013-02-04T08:52:27Z" , "dc.date.issued": "2011" , "dc.identifier.issn": "1471-2261" , "dc.identifier.uri": "http://hdl.handle.net/10256/7489" , "dc.description.abstract": "Background: Cardiovascular risk functions fail to identify more than 50% of patients who develop cardiovascular disease. This is especially evident in the intermediate-risk patients in which clinical management becomes difficult. Our purpose is to analyze if ankle-brachial index (ABI), measures of arterial stiffness, postprandial glucose, glycosylated hemoglobin, self-measured blood pressure and presence of comorbidity are independently associated to incidence of vascular events and whether they can improve the predictive capacity of current risk equations in the intermediate-risk population. Methods/Design: This project involves 3 groups belonging to REDIAPP (RETICS RD06/0018) from 3 Spanish regions. We will recruit a multicenter cohort of 2688 patients at intermediate risk (coronary risk between 5 and 15% or vascular death risk between 3-5% over 10 years) and no history of atherosclerotic disease, selected at random. We will record socio-demographic data, information on diet, physical activity, comorbidity and intermittent claudication. We will measure ABI, pulse wave velocity and cardio ankle vascular index at rest and after a light intensity exercise. Blood pressure and anthropometric data will be also recorded. We will also quantify lipids, glucose and glycosylated hemoglobin in a fasting blood sample and postprandial capillary glucose. Eighteen months after the recruitment, patients will be followed up to determine the incidence of vascular events (later follow-ups are planned at 5 and 10 years). We will analyze whether the new proposed risk factors contribute to improve the risk functions based on classic risk factors. Discussion: Primary prevention of cardiovascular diseases is a priority in public health policy of developed and developing countries. The fundamental strategy consists in identifying people in a high risk situation in which preventive measures are effective and efficient. Improvement of these predictions in our country will have an immediate, clinical and welfare impact and a short term public health effect" , "dc.format.mimetype": "application/pdf" , "dc.language.iso": "eng" , "dc.publisher": "BioMed Central" , "dc.relation.isformatof": "Reproducció digital del document publicat a: http://dx.doi.org/10.1186/1471-2261-11-61" , "dc.relation.ispartof": "BMC Cardiovascular Disorders, 2011, vol. 11, núm. 61" , "dc.relation.ispartofseries": "Articles publicats (D-CM)" , "dc.rights": "Attribution 2.0 Spain" , "dc.rights.uri": "http://creativecommons.org/licenses/by/2.0/es/" , "dc.subject": "Sistema cardiovascular -- Malalties" , "dc.subject": "Atenció primària" , "dc.subject": "Primary care (Medicine)" , "dc.subject": "Riscos per a la salut -- Avaluació" , "dc.subject": "Health risk assessment" , "dc.subject": "Sistema cardiovascular -- Prevenció" , "dc.subject": "Cardiovascular system -- Prevention" , "dc.subject": "Cardiovascular system -- Diseases" , "dc.title": "Improving interMediAte Risk management. MARK study" , "dc.type": "info:eu-repo/semantics/article" , "dc.rights.accessRights": "info:eu-repo/semantics/openAccess" , "dc.type.version": "info:eu-repo/semantics/publishedVersion" , "dc.identifier.doi": "http://dx.doi.org/10.1186/1471-2261-11-61" , "dc.identifier.idgrec": "019329" , "dc.identifier.eissn": "1471-2261" }