{ "dc.contributor.author": "Mayneris Perxachs, Jordi" , "dc.contributor.author": "Castells Nobau, Anna" , "dc.contributor.author": "Arnoriaga Rodríguez, María" , "dc.contributor.author": "Martín Sánchez, Miquel" , "dc.contributor.author": "Vega-Correa, Lisset de la" , "dc.contributor.author": "Zapata Tona, Cristina" , "dc.contributor.author": "Burokas, Aurelijus" , "dc.contributor.author": "Blasco Solà, Gerard" , "dc.contributor.author": "Coll-Martinez, Clàudia" , "dc.contributor.author": "Escrichs, Anira" , "dc.contributor.author": "Biarnés, Carles" , "dc.contributor.author": "Moreno Navarrete, José María" , "dc.contributor.author": "Puig Alcántara, Josep" , "dc.contributor.author": "Garre Olmo, Josep" , "dc.contributor.author": "Ramos Blanes, Rafel" , "dc.contributor.author": "Pedraza, S." , "dc.contributor.author": "Brugada, Ramon" , "dc.contributor.author": "Vilanova, Joan Carles" , "dc.contributor.author": "Serena, Joaquín" , "dc.contributor.author": "Gich Fullà, Jordi" , "dc.contributor.author": "Ramió i Torrentà, Lluís" , "dc.contributor.author": "Pérez Brocal, Vicente" , "dc.contributor.author": "Moya, Andrés" , "dc.contributor.author": "Pamplona, Reinald" , "dc.contributor.author": "Sol, Joaquim" , "dc.contributor.author": "Jové, Mariona" , "dc.contributor.author": "Ricart, Wifredo" , "dc.contributor.author": "Portero Otin, Manuel" , "dc.contributor.author": "Deco, Gustavo" , "dc.contributor.author": "Maldonado, Rafael" , "dc.contributor.author": "Fernández-Real Lemos, José Manuel" , "dc.date.accessioned": "2024-02-20T15:19:01Z" , "dc.date.available": "2024-02-20T15:19:01Z" , "dc.date.issued": "2022-05-03" , "dc.identifier.issn": "1550-4131" , "dc.identifier.uri": "http://hdl.handle.net/10256/24504" , "dc.description.abstract": "The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied a multi-omics approach combining pre-clinical models with three human cohorts including patients with mild depression. Microbial functions and metabolites converging onto glutamate/GABA metabolism, particularly proline, were linked to depression. High proline consumption was the dietary factor with the strongest impact on depression. Whole-brain dynamics revealed rich club network disruptions associated with depression and circulating proline. Proline supplementation in mice exacerbated depression along with microbial translocation. Human microbiota transplantation induced an emotionally impaired phenotype in mice and alterations in GABA-, proline-, and extracellular matrix-related prefrontal cortex genes. RNAi-mediated knockdown of proline and GABA transporters in Drosophila and mono-association with L. plantarum, a high GABA producer, conferred protection against depression-like states. Targeting the microbiome and dietary proline may open new windows for efficient depression treatment" , "dc.format.extent": "21 p." , "dc.format.mimetype": "application/pdf" , "dc.language.iso": "eng" , "dc.publisher": "Elsevier (Cell Press)" , "dc.relation.isformatof": "Reproducció digital del document publicat a: https://doi.org/10.1016/j.cmet.2022.04.001" , "dc.relation.ispartof": "Cell Metabolism, 2022, vol. 34, núm. 5, p. 681-701" , "dc.relation.ispartofseries": "Articles publicats (D-CM)" , "dc.rights": "Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional" , "dc.rights.uri": "http://creativecommons.org/licenses/by-nc-nd/4.0" , "dc.source": "Mayneris Perxachs, Jordi Castells Nobau, Anna Arnoriaga Rodríguez, María Martín Sánchez, Miquel Vega-Correa, Lisset de la Zapata Tona, Cristina Burokas, Aurelijus Blasco Solà, Gerard Coll-Martinez, Clàudia Escrichs, Anira Biarnés, Carles Moreno Navarrete, José María Puig Alcántara, Josep Garre Olmo, Josep Ramos Blanes, Rafel Pedraza, S. Brugada, Ramon Vilanova, Joan Carles Serena, Joaquín Gich Fullà, Jordi Ramió i Torrentà, Lluís Pérez Brocal, Vicente Moya, Andrés Pamplona, Reinald Sol, Joaquim Jové, Mariona Ricart, Wifredo Portero Otin, Manuel Deco, Gustavo Maldonado, Rafael Fernández-Real Lemos, José Manuel 2022 Microbiota alterations in proline metabolism impact depression Cell Metabolism 34 5 681 701" , "dc.subject": "Depressió psíquica" , "dc.subject": "Mental depression" , "dc.subject": "Intestins -- Microbiologia" , "dc.subject": "Intestines -- Microbiology" , "dc.title": "Microbiota alterations in proline metabolism impact depression" , "dc.type": "info:eu-repo/semantics/article" , "dc.rights.accessRights": "info:eu-repo/semantics/openAccess" , "dc.type.version": "info:eu-repo/semantics/publishedVersion" , "dc.identifier.doi": "https://doi.org/10.1016/j.cmet.2022.04.001" , "dc.identifier.idgrec": "036100" , "dc.type.peerreviewed": "peer-reviewed" , "dc.identifier.eissn": "1932-7420" }