{ "dc.contributor.author": "Perez-Serra, Alexandra" , "dc.contributor.author": "Toro, Rocío" , "dc.contributor.author": "Sarquella Brugada, Geòrgia" , "dc.contributor.author": "Gonzalo-Calvo, David de" , "dc.contributor.author": "Cesar, Sergi" , "dc.contributor.author": "Carro, Esther" , "dc.contributor.author": "Llorente-Cortes, Vicenta" , "dc.contributor.author": "Iglesias, Anna" , "dc.contributor.author": "Brugada Terradellas, Josep" , "dc.contributor.author": "Brugada, Ramon" , "dc.contributor.author": "Campuzano Larrea, Oscar" , "dc.date.accessioned": "2024-02-05T12:47:21Z" , "dc.date.available": "2024-02-05T12:47:21Z" , "dc.date.issued": "2016-12-01" , "dc.identifier.issn": "0167-5273" , "dc.identifier.uri": "http://hdl.handle.net/10256/24314" , "dc.description.abstract": "Dilated cardiomyopathy is a rare cardiac disease characterized by left ventricular dilatation and systolic dysfunction leading to heart failure and sudden cardiac death. Currently, despite several conditions have been reported as aetiologies of the disease, a large number of cases remain classified as idiopathic. Recent studies determine that nearly 60% of cases are inherited, therefore due to a genetic cause. Progressive technological advances in genetic analysis have identified over 60 genes associated with this entity, being TTN the main gene, so far. All these genes encode a wide variety of myocyte proteins, mainly sarcomeric and desmosomal, but physiopathologic pathways are not yet completely unraveled. We review the recent published data about genetics of familial dilated cardiomyopathy" , "dc.format.extent": "12 p." , "dc.format.mimetype": "application/pdf" , "dc.language.iso": "eng" , "dc.publisher": "Elsevier" , "dc.relation.isformatof": "Versió postprint del document publicat a: https://doi.org/10.1016/j.ijcard.2016.09.068" , "dc.relation.ispartof": "© International Journal of Cardiology, 2016, vol. 224, p. 461-472" , "dc.relation.ispartofseries": "Articles publicats (D-CM)" , "dc.rights": "Tots els drets reservats" , "dc.source": "Perez-Serra, Alexandra Toro R Sarquella-Brugada G de Gonzalo-Calvo D Cesar S Carro E Llorente-Cortes V Iglesias A Brugada J Brugada, Ramon Campuzano Larrea, Oscar 2016 Genetic basis of dilated cardiomyopathy International Journal of Cardiology 224 461 472" , "dc.subject": "Cardiopatia congènita" , "dc.subject": "Congenital heart disease" , "dc.subject": "Mort sobtada" , "dc.subject": "Sudden death" , "dc.subject": "Genètica" , "dc.subject": "Genetics" , "dc.subject": "Miocardi -- Malalties" , "dc.subject": "Myocardium -- Diseases" , "dc.title": "Genetic basis of dilated cardiomyopathy" , "dc.type": "info:eu-repo/semantics/article" , "dc.rights.accessRights": "info:eu-repo/semantics/openAccess" , "dc.type.version": "info:eu-repo/semantics/acceptedVersion" , "dc.identifier.doi": "https://doi.org/10.1016/j.ijcard.2016.09.068" , "dc.identifier.idgrec": "025872" , "dc.type.peerreviewed": "peer-reviewed" , "dc.identifier.eissn": "1874-1754" }