{ "dc.contributor.author": "Kühne, Britta A." , "dc.contributor.author": "Puig i Miquel, Teresa" , "dc.contributor.author": "Ruiz Martínez, Santiago" , "dc.contributor.author": "Crous Masó, Joan" , "dc.contributor.author": "Planas i Grabuleda, Marta" , "dc.contributor.author": "Feliu Soley, Lídia" , "dc.contributor.author": "Cano, Amanda" , "dc.contributor.author": "García, Maria Luisa" , "dc.contributor.author": "Fritsche, Ellen" , "dc.contributor.author": "Llobet, Joan M." , "dc.contributor.author": "Gómez-Catalán, Jesús" , "dc.contributor.author": "Barenys, Marta" , "dc.date.accessioned": "2019-01-18T11:35:32Z" , "dc.date.available": "2019-01-18T11:35:32Z" , "dc.date.issued": "2019-01-01" , "dc.identifier.issn": "0278-6915" , "dc.identifier.uri": "http://hdl.handle.net/10256/16209" , "dc.description.abstract": "Epigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation as a potential therapeutic or preventive treatment during pregnancy against developmental adverse effects induced by toxic substances. However, the safety of EGCG during pregnancy is unclear due to its proven adverse effects on neural progenitor cells' (NPCs) migration. As lately several strategies have arisen to generate new therapeutic agents derived from EGCG, we have used the rat 'Neurosphere Assay' to characterize and compare the effects of EGCG structurally related compounds and EGCG PEGylated PLGA nanoparticles on a neurodevelopmental key event: NPCs migration. Compounds structurally-related to EGCG induce the same pattern of NPCs migration alterations (decreased migration distance, decreased formation of migration corona, chaotic orientation of cellular processes and decreased migration of neurons at higher concentrations). The potency of the compounds does not depend on the number of galloyl groups, and small structure variations can imply large potency differences. Due to their lower toxicity observed in vitro in NPCs, 4,4′-bis[(3,4,5-trihydroxybenzoyl)oxy]-1,1′-biphenyl and EGCG PEGylated PLGA nanoparticles are suggested as potential future therapeutic or preventive alternatives to EGCG during prenatal period" , "dc.format.extent": "10 p." , "dc.format.mimetype": "application/pdf" , "dc.language.iso": "eng" , "dc.publisher": "Elsevier" , "dc.relation.isformatof": "Versió postprint del document publicat a: https://doi.org/10.1016/j.fct.2018.10.055" , "dc.relation.ispartof": "© Food and Chemical Toxicology, 2019, vol. 123, p. 195-204" , "dc.relation.ispartofseries": "Articles publicats (D-Q)" , "dc.rights": "Tots els drets reservats" , "dc.source": "Kühne, Britta A. Puig i Miquel, Teresa Ruiz Martínez, Santiago Crous Masó, Joan Planas i Grabuleda, Marta Feliu Soley, Lídia Cano, Amanda García, Maria Luisa Fritsche, Ellen Llobet, Joan M. Gómez-Catalán, Jesús Barenys, Marta 2019 Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres Food and Chemical Toxicology 123 195 204" , "dc.subject": "Catequines -- Ús terapèutic" , "dc.subject": "Catechins -- Therapeutic use" , "dc.title": "Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres" , "dc.type": "info:eu-repo/semantics/article" , "dc.rights.accessRights": "info:eu-repo/semantics/embargoedAccess" , "dc.embargo.lift": "2020-01-01T00:00:00Z" , "dc.embargo.terms": "2020-01-01T00:00:00Z" , "dc.date.embargoEndDate": "info:eu-repo/date/embargoEnd/2020-01-01" , "dc.type.version": "info:eu-repo/semantics/acceptedVersion" , "dc.identifier.doi": "https://doi.org/10.1016/j.fct.2018.10.055" , "dc.identifier.idgrec": "029183" , "dc.type.peerreviewed": "peer-reviewed" }