IV paracetamol versus IV ibuprofen for the treatment of PDA in LBW infants: a randomized controlled trial
dc.contributor
dc.contributor.author
dc.contributor.other
dc.date.accessioned
2014-03-31T09:06:00Z
dc.date.available
2014-03-31T09:06:00Z
dc.date.issued
2014-01-20
dc.identifier.uri
dc.description.abstract
Patent ductus arteriosus is a prevalent problem in low birth weight infants and it has an important morbidity and mortality in this group of patients. Classical treatment options include drugs (intravenous cyclooxygenase inhibitors: indomethacin and ibuprofen) and surgical ligation, but these treatments are associated with significant adverse effects. An alternative treatment with fewer side effects is needed. The role of oral paracetamol has gained importance in recent years, this new therapeutic option is being widely studied, and there are already many studies which support oral paracetamol as first line treatment for PDA, due to its better safety profile than classical drugs. In LBW infants is difficult to administer enteral treatment, since they are often multi pathological patients with several complications that preclude oral administration and they usually receive intravenous treatments. This multicenter, prospective, single blinded, randomized, controlled, parallel-group and noninferiority trial is designed to evaluate the efficacy and safety of intravenous paracetamol versus intravenous ibuprofen in the treatment of PDA in LBW infants. Sixty eight infants with echocardiography confirmed PDA will be randomly assigned to receive either intravenous paracetamol or intravenous ibuprofen. The main endpoints will be the rate of ductal closure of each drug and adverse events in each group of treatment
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.relation.ispartofseries
Medicina (TFG)
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.uri
dc.title
IV paracetamol versus IV ibuprofen for the treatment of PDA in LBW infants: a randomized controlled trial
dc.type
info:eu-repo/semantics/bachelorThesis
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.coverage.geolocation
east=2.81998872756958; north=41.997510603567896; name=Hospital Universitari de Girona Doctor Josep Trueta
east=2.1418727000000217; north=41.4278967; name=Hospital Universitari Vall d'Hebron
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