Evaluation of potential breath biomarkers for active smoking: assessment of smoking habits
dc.contributor.author
dc.date.accessioned
2013-05-29T10:52:38Z
dc.date.available
2014-05-30T03:00:08Z
dc.date.issued
2010-04
dc.identifier.issn
1618-2642
dc.identifier.uri
dc.description
The final publication is available at link.springer.com
dc.description.abstract
Different compounds have been reported as biomarkers of a smoking habit, but, to date, there is no appropriate biomarker for tobacco-related exposure because the proposed chemicals seem to be nonspecific or they are only appropriate for short-term exposure. Moreover, conventional sampling methodologies require an invasive method because blood or urine samples are required. The use of a microtrap system coupled to gas chromatography–mass spectrometry analysis has been found to be very effective for the noninvasive analysis of volatile organic compounds in breath samples. The levels of benzene, 2,5-dimethylfuran, toluene, o-xylene, and m- p-xylene have been analyzed in breath samples obtained from 204 volunteers (100 smokers, 104 nonsmokers; 147 females, 57 males; ages 16 to 53 years). 2,5-Dimethylfuran was always below the limit of detection (0.005 ppbv) in the nonsmoker population and always detected in smokers independently of the smoking habits. Benzene was only an effective biomarker for medium and heavy smokers, and its level was affected by smoking habits. Regarding the levels of xylenes and toluene, they were only different in heavy smokers and after short-term exposure. The results obtained suggest that 2,5-dimethylfuran is a specific breath biomarker of smoking status independently of the smoking habits (e.g., short- and long-term exposure, light and heavy consumption), and so this compound might be useful as a biomarker of smoking exposure
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.relation.isformatof
Versió postprint del document publicat a: http://dx.doi.org/10.1007/s00216-010-3524-z
dc.relation.ispartof
© Analytical and Bioanalytical Chemistry, vol. 396, núm. 8, p. 2987-2995
dc.relation.ispartofseries
Articles publicats (D-Q)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Evaluation of potential breath biomarkers for active smoking: assessment of smoking habits
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.identifier.idgrec
012056
dc.identifier.eissn
1618-2650