DUGiDocsMicroviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways
Text Complet
02_art_050924.pdf
Figure 1_revised_v2.pdf
Figure 2_v2.pdf
Figure 3_revised_no_highlight.pdf
Figure 4_Revised_v4.pdf
Figure 5_revised_V3.pdf
Figure 6_revised.pdf
Figure 7_revised.pdf
Figure 8_revised_GIRADA_FINAL.pdf
Figure S1.pdf
Figure S2_revised.pdf
Figure S3_waist_circ.pdf
Figure S4_revised.pdf
Figure S5_revised_V2.pdf
Figure S6_revised.pdf
Figure S7_revised.pdf
Figure S8_agrupada_v2.pdf
Figure S9.pdf
Figure S10_New_v2.pdf
Figure 1_revised_v2.pdf
Figure 2_v2.pdf
Figure 3_revised_no_highlight.pdf
Figure 4_Revised_v4.pdf
Figure 5_revised_V3.pdf
Figure 6_revised.pdf
Figure 7_revised.pdf
Figure 8_revised_GIRADA_FINAL.pdf
Figure S1.pdf
Figure S2_revised.pdf
Figure S3_waist_circ.pdf
Figure S4_revised.pdf
Figure S5_revised_V2.pdf
Figure S6_revised.pdf
Figure S7_revised.pdf
Figure S8_agrupada_v2.pdf
Figure S9.pdf
Figure S10_New_v2.pdf
Sol·licita còpia a l'autor de l'article
En omplir aquest formulari esteu demanant una còpia de l'article dipositat al repositori institucional (DUGiDocs) al seu autor o a l'autor principal de l'article. Serà el mateix autor qui decideixi lliurar una còpia del document a qui ho sol•liciti si ho creu convenient. En tot cas, la Biblioteca de la UdG no intervé en aquest procés ja que no està autoritzada a facilitar articles quan aquests són d'accés restringit.
Food addiction contributes to the obesity pandemic, but the connection between how the gut microbiome is linked to food addiction remains largely unclear. Here we show that Microviridae bacteriophages, particularly Gokushovirus WZ-2015a, are associated with food addiction and obesity across multiple human cohorts. Further analyses reveal that food addiction and Gokushovirus are linked to serotonin and dopamine metabolism. Mice receiving faecal microbiota and viral transplantation from human donors with the highest Gokushovirus load exhibit increased food addiction along with changes in tryptophan, serotonin and dopamine metabolism in different regions of the brain, together with alterations in dopamine receptors. Mechanistically, targeted tryptophan analysis shows lower anthranilic acid (AA) concentrations associated with Gokushovirus. AA supplementation in mice decreases food addiction and alters pathways related to the cycle of neurotransmitter synthesis release. In Drosophila, AA regulates feeding behaviour and addiction-like ethanol preference. In summary, this study proposes that bacteriophages in the gut microbiome contribute to regulating food addiction by modulating tryptophan and tyrosine metabolism
Tots els drets reservats