Challenges and Novel Opportunities of Radiation Therapy for Brain Metastases in Non-Small Cell Lung Cancer
dc.contributor.author
dc.date.accessioned
2024-07-15T08:13:02Z
dc.date.available
2024-07-15T08:13:02Z
dc.date.issued
2021-04-29
dc.identifier.issn
2072-6694
dc.identifier.uri
dc.description.abstract
Approximately 20% patients with non-small cell lung cancer (NSCLC) present with CNS spread at the time of diagnosis and 25-50% are found to have brain metastases (BMs) during the course of the disease. The improvement in the diagnostic tools and screening, as well as the use of new systemic therapies have contributed to a more precise diagnosis and prolonged survival of lung cancer patients with more time for BMs development. In the past, most of the systemic therapies failed intracranially because of the inability to effectively cross the blood brain barrier. Some of the new targeted therapies, especially the group of tyrosine kinase inhibitors (TKIs) have shown durable CNS response. However, the use of ionizing radiation remains vital in the management of metastatic brain disease. Although a decrease in CNS-related deaths has been achieved over the past decade, many challenges arise from the need of multiple and repeated brain radiation treatments, which carry along not insignificant risks and toxicity. The combination of stereotactic radiotherapy and systemic treatments in terms of effectiveness and adverse effects, such as radionecrosis, remains a subject of ongoing investigation. This review discusses the challenges of the use of radiation therapy in NSCLC BMs in view of different systemic treatments such as chemotherapy, TKIs and immunotherapy. It also outlines the future perspectives and strategies for personalized BMs management
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
MDPI (Multidisciplinary Digital Publishing Institute)
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.3390/cancers13092141
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Cancers, 2021, vol. 13, núm. 9, p. 2141
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Articles publicats (D-CM)
dc.rights
Attribution 4.0 International (CC BY 4.0)
dc.rights.uri
dc.source
Jablonska, Paola Anna Bosch Barrera, Joaquim Serrano, Diego Valiente Malmagro, Manuel Calvo, Alfonso Aristu, Javier 2021 Challenges and Novel Opportunities of Radiation Therapy for Brain Metastases in Non-Small Cell Lung Cancer Cancers 13 9 2141
dc.title
Challenges and Novel Opportunities of Radiation Therapy for Brain Metastases in Non-Small Cell Lung Cancer
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
038993
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
2072-6694
dc.identifier.PMID
33946751
dc.identifier.PMCID
8124815