Matrix Effect on Singlet Oxygen Generation Using Methylene Blue as Photosensitizer
dc.contributor.author
dc.date.accessioned
2024-06-05T05:53:36Z
dc.date.available
2024-06-05T05:53:37Z
dc.date.issued
2024-05-31
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dc.description.abstract
Methylene blue (MB) is a well-established and extensively studied photosensitizer for photodynamic therapy (PDT), since it can generate singlet oxygen with a high quantum yield upon irradiation within the phototherapeutic (600-950 nm) window. However, its activity can decrease due to the formation of dimers or higher aggregates, which can take place in an aqueous solution at relatively high concentrations. The incorporation of this molecule into a matrix can avoid this aggregation and increase its activity relative to PDT. Silica porous nanoparticles are chosen here as a matrix to host MB. The size and pore geometry are tuned in order to decrease MB leaching while maintaining good singlet oxygen generation and colloidal stability for further applications in nanomedicine. In addition, phenyl functions are grafted on the pores of the silica matrix in order to avoid MB aggregation, thereby increasing the activity of the photosensitizer in the singlet oxygen generation. DFT calculations give insight in the structure of the aggregation of the MB units, and the roles of water and organic environments are investigated through time-dependent calculations on UV-vis spectra
dc.description.sponsorship
This research was funded by CNRS UMR-5182 and the Ecole Normale Supérieure de Lyon; the Spanish MINECO, for project PID2021-127423NB-I00; and the Generalitat de Catalunya, for project 2021SGR623
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
MDPI (Multidisciplinary Digital Publishing Institute)
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Reproducció digital del document publicat a: https://doi.org/10.3390/inorganics12060155
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Inorganics, 2024, vol. 12, núm. 6, p. 155
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Articles publicats (D-Q)
dc.rights
Reconeixement 4.0 Internacional
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dc.source
Xu, Jianan Bonneviot, Laurent Guari, Yannick Monnereau, Cyrille Zhang, Kun Poater Teixidor, Albert Rodríguez Pizarro, Montserrat Albela, Belén 2024 Matrix Effect on Singlet Oxygen Generation Using Methylene Blue as Photosensitizer Inorganics 12 6 155
dc.subject
dc.title
Matrix Effect on Singlet Oxygen Generation Using Methylene Blue as Photosensitizer
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.relation.projectID
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127423NB-I00/ES/CATALISIS PREDICTIVA PARA CAMBIAR EL ODEN SECUENCIAL ENTRE EXPERIMENTOS I CALCULOS/
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
038881
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
2304-6740