Arc protein expression after unilateral intracranial self-stimulation of the medial forebrain bundle is upregulated in specific nuclei of memory-related areas
dc.contributor.author
dc.date.accessioned
2024-02-06T09:48:45Z
dc.date.available
2024-02-06T09:48:47Z
dc.date.issued
2018-08-08
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dc.description.abstract
Background Intracranial Self-Stimulation (ICSS) of the medial forebrain bundle (MFB) is a deep brain stimulation procedure, which has a powerful enhancement effect on explicit and implicit memory. However, the downstream synaptic plasticity events of MFB-ICSS in memory related areas have not been described thoroughly. This study complements previous work studying the effect of MFB-ICSS on the expression of the activity-regulated cytoskeleton-associated (Arc) protein, which has been widely established as a synaptic plasticity marker. We provide new integrated measurements from memory related regions and take possible regional hemispheric differences into consideration. Results Arc protein expression levels were analyzed 4.5 h after MFB-ICSS by immunohistochemistry in the hippocampus, habenula, and memory related amygdalar and thalamic nuclei, in both the ipsilateral and contralateral hemispheres to the stimulating electrode location. MFB-ICSS was performed using the same paradigm which has previously been shown to facilitate memory. Our findings illustrate that MFB-ICSS upregulates the expression of Arc protein in the oriens and radiatum layers of ipsilateral CA1 and contralateral CA3 hippocampal regions; the hilus bilaterally, the lateral amygdala and dorsolateral thalamic areas as well as the central medial thalamic nucleus. In contrast, the central amygdala, mediodorsal and paraventricular thalamic nuclei, and the habenular complex did not show changes in Arc expression after MFB-ICSS. Conclusions Our results expand our knowledge of which specific memory related areas MFB-ICSS activates and, motivates the definition of three functionally separate groups according to their Arc-related synaptic plasticity response: (1) the hippocampus and dorsolateral thalamic area, (2) the central medial thalamic area and (3) the lateral amygdala
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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Reproducció digital del document publicat a: https://doi.org/10.1186/s12868-018-0449-5
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BMC Neuroscience, 2018, vol. 19, núm. 48
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Articles publicats (D-B)
dc.rights
Attribution 4.0 International (CC BY 4.0)
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dc.source
Kádár García, Elisabeth Vico Varela, Eva Aldavert Vera, Laura Huguet i Blanco, Gemma Morgado-Bernal, Ignacio Segura i Torres, Pilar 2018 Arc protein expression after unilateral intracranial self-stimulation of the medial forebrain bundle is upregulated in specific nuclei of memory-related areas BMC Neuroscience 19 48
dc.subject
dc.title
Arc protein expression after unilateral intracranial self-stimulation of the medial forebrain bundle is upregulated in specific nuclei of memory-related areas
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
030379
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1471-2202