Alcohol as a trigger of migraine attacks in people with migraine. Results from a large prospective cohort study in English-speaking countries
dc.contributor.author
dc.date.accessioned
2022-12-16T12:27:26Z
dc.date.available
2022-12-16T12:27:26Z
dc.date.issued
2022-12-13
dc.identifier.issn
0017-8748
dc.identifier.uri
dc.description.abstract
Objective
To assess whether alcohol intake is associated with the onset of migraine attacks up to 2 days after consumption in individuals with episodic migraine (EM).
Background
Although alcohol has long been suspected to be a common migraine trigger, studies have been inconclusive in proving this association.
Methods
This was an observational prospective cohort study among individuals with migraine who registered to use a digital health platform for headache. Eligible individuals were aged ≥18 years with EM who consumed alcohol and had tracked their headache symptoms and alcohol intake for ≥90 days. People who did not drink any alcohol were excluded. The association of alcohol intake (“Yes/No”) and of the number of alcoholic beverages in the 2 days preceding a migraine attack was assessed accounting for the presence of migraine on day-2 and its interaction with alcohol intake on day-2, and further adjusted for sex, age, and average weekly alcohol intake.
Results
Data on 487 individuals reporting 5913 migraine attacks and a total of 40,165 diary days were included in the analysis. Presence of migraine on day-2 and its interaction with alcohol intake on day-2 were not significant and removed from the model. At the population level, alcohol intake on day-2 was associated with a lower probability of migraine attack (OR [95% CI] = 0.75 [0.68, 0.82]; event rate 1006/4679, 21.5%), while the effect of alcohol intake on day-1 was not significant (OR [95% CI] = 1.01 [0.91, 1.11]; event rate 1163/4679, 24.9%) after adjusting for sex, age, and average weekly alcohol intake. Similar results were obtained with the number of beverages as exposure.
Conclusions
In this English-speaking cohort of individuals with EM who identified themselves as mostly low-dose alcohol consumers, there was no significant effect on the probability of a migraine attack in the 24 h following consumption, and a slightly lower likelihood of a migraine attack from 24 to 48 h following use
dc.description.sponsorship
Open Access funding provided thanks to the CRUE-CSIC agreement with Wiley
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application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1111/head.14428
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Headache: The Journal of Head and Face Pain, 2022, vol. 62, núm. 10, p. 1329-1338
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Articles publicats (D-IMA)
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri
dc.subject
dc.title
Alcohol as a trigger of migraine attacks in people with migraine. Results from a large prospective cohort study in English-speaking countries
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1526-4610