Using population-based data to evaluate the impact of adherence to endocrine therapy on survival in breast cancer through the web-application BreCanSurvPred
dc.contributor.author
dc.date.accessioned
2022-07-29T09:48:51Z
dc.date.available
2022-07-29T09:48:51Z
dc.date.issued
2022-05-16
dc.identifier.uri
dc.description.abstract
We show how the use and interpretation of population-based cancer survival indicators can help oncologists talk with breast cancer (BC) patients about the relationship between their prognosis and their adherence to endocrine therapy (ET). The study population comprised a population-based cohort of estrogen receptor positive BC patients (N = 1268) diagnosed in Girona and Tarragona (Northeastern Spain) and classified according to HER2 status (+ / −), stage at diagnosis (I/II/III) and five-year cumulative adherence rate (adherent > 80%; non-adherent ≤ 80%). Cox regression analysis was performed to identify significant prognostic factors for overall survival, whereas relative survival (RS) was used to estimate the crude probability of death due to BC (PBC). Stage and adherence to ET were the significant factors for predicting all-cause mortality. Compared to stage I, risk of death increased in stage II (hazard ratio [HR] 2.24, 95% confidence interval [CI]: 1.51–3.30) and stage III (HR 5.11, 95% CI 3.46–7.51), and it decreased with adherence to ET (HR 0.57, 95% CI 0.41–0.59). PBC differences were higher in non-adherent patients compared to adherent ones and increased across stages: stage I: 6.61% (95% CI 0.05–13.20); stage II: 9.77% (95% CI 0.59–19.01), and stage III: 22.31% (95% CI 6.34–38.45). The age-adjusted survival curves derived from this modeling were implemented in the web application BreCanSurvPred (https://pdocomputation.snpstats.net/BreCanSurvPred). Web applications like BreCanSurvPred can help oncologists discuss the consequences of non-adherence to prescribed ET with patients
dc.description.sponsorship
Tis work was supported by Instituto de Salud Carlos III PI18/01836 funded by FEDER funds/European Regional
Development Fund (ERDF)-a way to Build Europe-//FONDOS FEDER “una manera de hacer Europa”. We also
acknowledge the support of Agència d’Avaluació d’Universitats i Recerca (2017SGR00735) from Generalitat de
Catalunya and PGC2018-095931-B-100 (MCIU/AEI/FEDER, UE). We also thank CERCA Programme/Generalitat de Catalunya for institutional support
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Nature Research
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1038/s41598-022-12228-y
dc.relation.ispartof
Scientific Reports, 2022, vol. 12, art.núm. 8097
dc.relation.ispartofseries
Articles publicats (D-I)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.subject
dc.title
Using population-based data to evaluate the impact of adherence to endocrine therapy on survival in breast cancer through the web-application BreCanSurvPred
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
035418
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
2045-2322