DUGiDocsCecal Ligation and Puncture-Induced Sepsis Promotes Brown Adipose Tissue Inflammation Without Any Impact on Expression of Thermogenic-Related Genes
dc.contributor.author
dc.date.accessioned
2022-01-13T13:16:04Z
dc.date.available
2022-01-13T13:16:04Z
dc.date.issued
2021-07-12
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dc.description.abstract
Background and Aims: The negative effects of chronic low-level inflammation on adipose tissue physiology have been extensively demonstrated, whereas the effects of acute inflammation are less studied. Here, we aimed to investigate the effects of sepsis-induced acute inflammation on gene expression markers of brown and white adipose tissue functionality.
Methods: Brown adipose tissue (BAT) and perirenal white adipose tissue (prWAT) gene expression markers were analyzed in cecal ligation and puncture (CLP)-induced sepsis mice model.
Results: CLP-induced sepsis attenuated expression of adipogenesis-related genes, in parallel to increased Tnf, Il6, and Ltf gene expression in prWAT. In contrast, CLP-induced sepsis resulted in increased expression of pro-inflammatory genes (Il6, Ltf, and Lbp) in BAT, without affecting expression of genes encoding for thermogenic activity.
Conclusion: Sepsis promotes both prWAT and BAT inflammation, associated with reduced adipogenesis-related gene expression in prWAT, without significant effects on BAT thermogenic genes
dc.description.sponsorship
This work was partially supported by research grants PI16/01173 and PI19/01712 from the Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional (FEDER). CIBEROBN Fisiopatología de la Obesidad y Nutrición is an initiative from the Instituto de Salud Carlos III. Additionally, the work is supported by a Kolff Junior Postdoc grant 16OKG06 from the Dutch Kidney Foundation and a Mandema Stipend from the University Medical Center Groningen awarded to H
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application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
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Reproducció digital del document publicat a: https://doi.org/10.3389/fphys.2021.692618
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Frontiers in Physiology, 2021, vol. 12, art.núm. 692618
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Articles publicats (D-CM)
dc.rights
Attribution 4.0 International
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dc.subject
dc.title
Cecal Ligation and Puncture-Induced Sepsis Promotes Brown Adipose Tissue Inflammation Without Any Impact on Expression of Thermogenic-Related Genes
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
033896
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1664-042X