DUGiDocsSome thoughts on counts in sequencing studies
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Measurements in sequencing studies are mostly
based on counts. There is a lack of theoretical developments
for the analysis and modelling of this type of
data. Some thoughts in this direction are presented,
which might serve as a seed. The main issues addressed
are the compositional character of multinomial
probabilities and the corresponding representation
in orthogonal (isometric) coordinates, and modelling
distributions for sequencing data taking into
account possible effects of amplification techniques
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