Can capnography use during sepsis treatment reduce mortality by improving hemodynamic management?

Abstract

Background: Sepsis and septic shock are life-threatening pathologies with an elevated mortality. Recent scientific evidence is showing that the most decisive period to affect mortality and prognosis when treating those pathologies is the first hour of treatment, named “Golden Hour”. Also, new evidence has shown the utility of capnography as a perfusion monitoring tool, even showing to be a better measurement than MAP for volume responsiveness. Objective: This study aims to demonstrate that a new protocol in hemodynamic management, using capnography as a volume responsiveness monitoring tool, in order to detect earlier those patients in which vasoactive drugs will be needed to guarantee perfusion, can reduce mortality by letting ED teams act earlier, as it is indicated in the new scientific consensus.

Design: This is a randomized, controlled, transversal study carried out by the Emergency Department of Hospital Universitari Doctor Josep Trueta de Girona. A non-probabilistic sampling method will be performed, including all patients for which septic code is activated in this centre from February 2021 to January 2024