A Bifunctional Peptide Conjugate That Controls Infections of Erwinia amylovora in Pear Plants
dc.contributor.author
dc.date.accessioned
2021-06-08T10:07:40Z
dc.date.available
2021-06-08T10:07:40Z
dc.date.issued
2021-06-05
dc.identifier.uri
dc.description.abstract
In this paper, peptide conjugates were designed and synthesized by incorporating the antimicrobial undecapeptide BP16 at the C- or N-terminus of the plant defense elicitor peptide flg15, leading to BP358 and BP359, respectively. The evaluation of their in vitro activity against six plant pathogenic bacteria revealed that BP358 displayed MIC values between 1.6 and 12.5 μM, being more active than flg15, BP16, BP359, and an equimolar mixture of BP16 and flg15. Moreover, BP358 was neither hemolytic nor toxic to tobacco leaves. BP358 triggered the overexpression of 6 out of the 11 plant defense-related genes tested. Interestingly, BP358 inhibited Erwinia amylovora infections in pear plants, showing slightly higher efficacy than the mixture of BP16 and flg15, and both treatments were as effective as the antibiotic kasugamycin. Thus, the bifunctional peptide conjugate BP358 is a promising agent to control fire blight and possibly other plant bacterial diseases
dc.description.sponsorship
This research was funded by MINECO/FEDER, UE, grant number AGL2015-69876-C2-2-R, by the Universitat de Girona, grant number MPCUdG2016/038, and by MCIU/AEI/FEDER, UE, grant number RTI2018-099410-B-C22
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
MDPI (Multidisciplinary Digital Publishing Institute)
dc.relation
info:eu-repo/grantAgreement/MINECO//AGL2015-69876-C2-2-R/ES/PEPTIDOS CONJUGADOS PARA EL CONTROL DE BACTERIAS FITOPATOGENAS DE CUARENTENA/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099410-B-C22/ES/PEPTIDOS DIRIGIDOS A DIANAS Y PROCESOS CLAVE PARA EL CONTROL DE XYLELLA FASTIDIOSA. DISEÑO, SINTESIS Y OPTIMIZACION/
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.3390/molecules26113426
dc.relation.ispartof
Molecules, 2021, vol. 26, núm. 11, p. 3426
dc.relation.ispartofseries
Articles publicats (D-Q)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.title
A Bifunctional Peptide Conjugate That Controls Infections of Erwinia amylovora in Pear Plants
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
033497
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
1420-3049