2,5-Dimethylfuran as a Validated Biomarker of Smoking Status
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dc.date.accessioned
2021-05-21T11:51:08Z
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2021-05-21T11:51:08Z
dc.date.issued
2019-06-01
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1462-2203
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dc.description.abstract
Introduction Exposure biomarkers are required in tobacco use studies to accurately assess smoking status since self-reporting usually results in misclassification estimates. This study uses breath analysis and assesses some volatile organic compounds (VOCs) as potential biomarkers of tobacco smoke exposure. Methods Forced-expiratory breath samples were obtained from 377 volunteers (174 smokers and 203 nonsmokers). Exhaled breath levels of different VOCs previously related to tobacco smoke were evaluated. The toluene-to-benzene ratio was evaluated as this ratio has been found to be different in atmospheric samples and tobacco smoke emissions. Finally, breath analyses from 64 patients attending a clinical practice were evaluated and the results were compared to their self-reporting status. Results Univariate analysis shows that all compounds evaluated gave significant differences (p < .001). Receiver operating characteristic (ROC) curves suggest that xylenes and toluene are not able to accurately determine smoking status, and benzene and the T/B ratio present potential utility in certain conditions. The highest discriminant capacity was obtained for 2,5-dimethylfuran (AUC = 0.982, 95% confidence interval [CI]: 0.969-0.995), with a cut-off value of 0.016 ppbv (sensibility = 0.965, specificity = 0.896). Drinking coffee was the only confounding parameter that can give low breath levels for this compound. The evaluation of the results obtained from the patients attending a clinical practice showed that 8% of people who claim to be nonsmokers hid their real smoking status. Conclusions The results obtained confirm that the determination of 2,5-dimethylfuran in breath samples is a good and simpler alternative to conventional blood or urine tests for assessing smoking status
dc.description.sponsorship
This study has been supported by the University of Girona (MPCUdG2016/100)
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7 p.
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application/pdf
dc.language.iso
eng
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Versió postprint del document publicat a: https://doi.org/10.1093/ntr/nty078
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© Nicotine & Tobacco Research, 2019, vol. 21, núm. 6, p. 828-834
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Articles publicats (D-Q)
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Tots els drets reservats
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Castellanos, María del Mar Suñer Soler, Rosa Fernández-Real Lemos, José Manuel Sánchez Navarro, Juan Manuel 2019 2,5-Dimethylfuran as a Validated Biomarker of Smoking Status Nicotine & Tobacco Research 21 6 828 834
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dc.title
2,5-Dimethylfuran as a Validated Biomarker of Smoking Status
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info:eu-repo/semantics/article
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info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.identifier.idgrec
030133
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1469-994X