Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation
dc.contributor.author
dc.date.accessioned
2021-02-09T10:51:46Z
dc.date.available
2021-04-07T08:02:59Z
dc.date.issued
2020-03-01
dc.identifier.issn
1074-7427
dc.identifier.uri
dc.description.abstract
Intracranial self-stimulation (ICSS) of the medial forebrain bundle is an effective treatment to facilitate memory. Performance in both explicit and implicit memory tasks has been improved by ICSS, and this treatment has even been capable of recovering loss of memory function due to lesions or old age. Several neurochemical systems have been studied in regard to their role in ICSS effects on memory, however the possible involvement of the orexinergic system in this facilitation has yet to be explored. The present study aims to examine the relationship between the OX1R and the facilitative effects of ICSS on two different types of memory tasks, both carried out in the Morris Water Maze: spatial and visual discrimination. Results show that the OX1R blockade, by intraventricular administration of SB-334867, partially negates the facilitating effect of ICSS on spatial memory, whereas it hinders ICSS facilitation of the discrimination task. However, ICSS treatment was capable of compensating for the severe detrimental effects of OX1R blockade on both memory paradigms. These results suggest different levels of involvement of the orexinergic system in the facilitation of memory by ICSS, depending on the memory task
dc.description.sponsorship
This research was supported by the Spanish Ministerio de Economía y
Competitvidad via I+D projects: PSI2013-41018-P, PSI2017-83202-C2-1-P and PSI2017-83202-C2-2-P and predoctoral grant (BES-2014-068393).
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2017-83202-C2-2-P/ES/POTENCIACION DE LA PLASTICIDAD NEURAL EN RATAS SANAS Y EN UN MODELO DE ENFERMEDAD DE ALZHEIMER: ESTIMULACION CEREBRAL REFORZANTE Y SINERGIAS CON SUPLEMENTOS DIETETICOS./
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Versió postprint del document publicat a: https://doi.org/10.1016/j.nlm.2020.107188
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© Neurobiology of Learning and Memory, 2020, vol. 169, art. núm.107188
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Articles publicats (D-B)
dc.rights
Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
dc.rights.uri
dc.source
García-Brito, Soleil Aldavert Vera, Laura Huguet i Blanco, Gemma Kádár García, Elisabeth Segura i Torres, Pilar 2020 Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation Neurobiology of Learning and Memory 169 art. núm.107188
dc.subject
dc.title
Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.embargo.terms
2021-03-01T00:00:00Z
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2021-03-01
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.identifier.idgrec
031153
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
1095-9564