Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
dc.contributor.author
dc.date.accessioned
2020-11-09T09:00:58Z
dc.date.available
2020-11-09T09:00:58Z
dc.date.issued
2020-07-17
dc.identifier.issn
1661-7827
dc.identifier.uri
dc.description.abstract
We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010–2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances
dc.description.sponsorship
This work was
supported by Spanish Ministry of Economy and Competitiveness—Carlos III Institute of Health co-funded by
FEDER funds/European Regional Develpment Fund (ERDF)—A way to build Europe (PI08/1770, PI08/0533,
PI08/1359, PS09/00773-Cantabria, PI11/01403, PI11/02213, PI14/1219, PI15/00966, PI17/01280, RTIC RD06/0020/0095,
RD12/0036/0036, SV-09-CLINIC-1 and CIBERESP), by Juan de la Cierva (IJCI-2016-29502), by the Fundación
Marques de Valdecilla (API 10/09), by Obra Social CAJASTUR (SV-CAJASTUR-1), by the Recercaixa (2010ACUP
00310 and with the support of the Secretariat for Universities and Research of the Ministry of Business and
Knowledge of the Government of Catalonia (2017SGR1085). The ICGC CLL-Genome Project was funded
by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III
(ISCIII), PMP15/00007 and CIBERONC del ISCIII. ISGlobal is a member of the CERCA Programme, Generalitat
de Catalunya
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
MDPI (Multidisciplinary Digital Publishing Institute)
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.3390/ijerph17145174
dc.relation.ispartof
International Journal of Environmental Research and Public Health, 2020, vol. 17, núm. 14, p. 5174
dc.relation.ispartofseries
Articles publicats (IdIBGi)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.subject
dc.title
Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
032085
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1660-4601