Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Benavente, Yolanda
Agudo, Antonio
Jakszyn, Paula
Naudin, Sabine
Hosnijeh, Fatemeh Saberi
Gunter, Marc
Huybrechts, Inge
Ferrari, Pietro
Besson, Caroline
Mahamat-Saleh, Yahya
Kühn, Tilman
Kaaks, Rudolf
Boeing, Heiner
Lasheras, Cristina
Sánchez, María-José
Amiano, Pilar
Chirlaque, María Dolores
Ardanaz, Eva
Schmidt, Julie A.
Vineis, Paolo
Riboli, Elio
Trichopoulou, Antonia
Karakatsani, Anna
Valanou, Elisavet
Masala, Giovanna
Agnoli, Claudia
Tumino, Rosario
Sacerdote, Carlotta
Mattiello, Amalia
Skeie, Guri
Weiderpass, Elisabete
Jerkeman, Mats
Dias, Joana Alves
Späth, Florentin
Nilsson, Lena Maria
Dahm, Christina C.
Overvad, Kim
Tjønneland, Anne
Vermeulen, Roel
Nieters, Alexandra
Casabonne, Delphine
Introduction: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. Results: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Conclusions: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings ​
​Tots els drets reservats