NaV1.5 in embryonic heart development

Abstract

The voltage‐gated sodium (NaV) channel is essential for cardiomyocyte function. It is responsible for generating the rising phase of the cardiac action potential. The channel consists of a pore‐forming, α‐subunit, whose main cardiac isoform is NaV1.5, and one or two associated β‐subunits. Moreover, it is part of a macromolecular complex including a diverse set of interacting proteins, some of which are implicated in regulating its localization to specialized membrane domains of the cardiomyocyte sarcolemma