Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach
dc.contributor.author
dc.date.accessioned
2020-07-29T11:18:35Z
dc.date.available
2020-07-29T11:18:35Z
dc.date.issued
2020-10-01
dc.identifier.issn
0048-9697
dc.identifier.uri
dc.description.abstract
Bioaccumulation of pharmaceuticals in fish exposed to contaminated water can be shaped by their capability to metabolize these xenobiotics, affecting their toxicity and animal welfare. In this study the in vivo metabolization of the antidepressant venlafaxine by the juvenile marine fish meagre (Argyrosomus regius) was evaluated using a combined target and suspect screening analytical approach. Thirteen venlafaxine metabolites were identified, namely N-desmethylvenlafaxine and N,N-didesmethylvenlafaxine, which were unequivocally identified using analytical standards, and 11 more tentatively identified by suspect screening analysis, including two Phase II metabolites formed by amino acid conjugation. All of them were detected in the liver, while in plasma and brain only 9 and 6 metabolites, respectively, were detected. Based on these findings, for the first time, a tentative metabolization pathway of venlafaxine by A. regius is proposed. Contrarily to what happen in humans, N-demethylation was identified as the main route of metabolization of venlafaxine by fish. Our findings highlight species-specificity in the metabolization of venlafaxine and allow a better understanding of venlafaxine's toxicokinetic in fish. These results emphasize the need to investigate the biotransformation of xenobiotics by non-target organisms to have an integrated overview of their environmental exposure and to improve future evaluations of environmental risk assessment
dc.description.sponsorship
This work was funded by the 7th EU-FP (ECsafeSEAFOOD project; GA n° 311820) and the European Regional Development Fund (FEDER) and by Spanish Ministry of Economy and Competitiveness (PGE-2010). This work was also funded by the Spanish State Research Agency of the Spanish Ministry of Science, Innovation and Universities and European Fund for Regional Development (project PLAS-MED; FEDER-MCIU-AEI/CTM2017-89701-C3-2-R). Authors thank Generalitat de Catalunya through Consolidated Research Group (ICRA-ENV 2017 SGR 1124 & 2017 SGR 1404). ICRA researchers thank funding from CERCA program. Lúcia H.M.L.M. Santos thanks the Juan de la Cierva program (IJCI-2017-32747) and Sara Rodríguez-Mozaz thanks the Ramon y Cajal program (RYC-2014-16707) from the Spanish State Research Agency of the Spanish Ministry of Science, Innovation and Universities (AEI-MCIU). A. Jaén-Gil thanks the predoctoral grant from the Agency for Management of University and Research Grants (AGAUR) (2019FI_B2_00202) co-financed by the European Social Fund. A. Marques (IF program) and A.L. Maulvault (Project FishBudget PTDC/BIA-BMA/28630/2017) thank the Portuguese Foundation for Science and Technology
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTM2017-89701-C3-2-R/ES/MICROPLASTICOS Y MICROCONTAMINANTES EN LA COSTA MEDITERRANEA. TOXICIDAD E IMPACTO AMBIENTAL Y EN LA SALUD HUMANA/
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Versió postprint del document publicat a: https://doi.org/10.1016/j.scitotenv.2020.140226
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© Science of The Total Environment, 2020. vol. 737, art. núm. 140226
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Articles publicats (ICRA)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2022-10-01
dc.relation.projectID
info:eu-repo/grantAgreement/EC/FP7/311820/EU/Priority environmental contaminants in seafood: safety assessment, impact and public perception/ECSAFESEAFOOD
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
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