Effect-Based Identification of Hazardous Antibiotic Transformation Products after Water Chlorination
dc.contributor.author
dc.date.accessioned
2020-07-29T11:01:19Z
dc.date.available
2020-07-29T11:01:19Z
dc.date.issued
2020-06-26
dc.identifier.issn
0013-936X
dc.identifier.uri
dc.description.abstract
Antibiotic transformation products (TPs) generated during water treatment can be considered as an environmental concern, since they can retain part of the bioactivity of the parent compound. Effect-directed analysis (EDA) was applied for the identification of bioactive intermediates of azithromycin (AZI) and ciprofloxacin (CFC) after water chlorination. Fractionation of samples allowed the identification of bioactive intermediates by measuring the antibiotic activity and acute toxicity, combined with an automated suspect screening approach for chemical analysis. While the removal of AZI was in line with the decrease of bioactivity in chlorinated samples, an increase of bioactivity after complete removal of CFC was observed (at >0.5 mgCl2/L). Principal component analysis (PCA) revealed that some of the CFC intermediates could contribute to the overall toxicity of the chlorinated samples. Fractionation of bioactive samples identified that the chlorinated TP296 (generated from the destruction of the CFC piperazine ring) maintained 41%, 44%, and 30% of the antibiotic activity of the parent compound in chlorinated samples at 2.0, 3.0, and 4.0 mgCl2/L, respectively. These results indicate the spectrum of antibacterial activity can be altered by controlling the chemical substituents and configuration of the CFC structure with chlorine. On the other hand, the potential presence of volatile DBPs and fractionation losses do not allow for tentative confirmation of the main intermediates contributing to the acute toxic effects measured in chlorinated samples. Our results encourage further development of new and advanced methodologies to study the bioactivity of isolated unknown TPs to understand their hazardous effects in treated effluents
dc.description.sponsorship
This work was funded by the Spanish State Research Agency of
the Spanish Ministry of Science, Innovation and Universities
AEI-MICIU and the Fondo Europeo de Desarrollo Regional
under the National Program for Research Aimed at the
Challenges of Society (CTM2017-85335-R). The authors
acknowledge the support from the Economy and Knowledge
Department of the Catalan Government through the
Consolidated Research Group (ICRA-ENV 2017 SGR 1124
and 2017-SGR-1404). ICRA researchers are thankful for
funding from the CERCA program
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society (ACS)
dc.relation
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTM2017-85335-R/ES/COMO PREDECIR Y MINIMIZAR LA FORMACION DE NDMA EN AGUA POTABLE Y RECICLADA MEDIANTE TECNICAS ANALITICAS AVANZADAS/
dc.relation.isformatof
Versió postprint del document publicat a: https://doi.org/10.1021/acs.est.0c00944
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© Environmental Science and Technology, 2020, vol. 54, núm. 14, p. 9062-9073
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Articles publicats (ICRA)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Effect-Based Identification of Hazardous Antibiotic Transformation Products after Water Chlorination
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2021-06-26
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
1520-5851