Stratification of cancer and diabetes based on circulating levels of formate and glucose
dc.contributor.author
dc.date.accessioned
2020-07-09T10:27:29Z
dc.date.available
2020-07-09T10:27:29Z
dc.date.issued
2019-04-24
dc.identifier.issn
2049-3002
dc.identifier.uri
dc.description
METTEN study group investigators: Sonia Pernas, Joan Dorca, Isabel Álvarez-López, Susana Martínez, Jose Manuel Pérez-García, Norberto Batista López, César A. Rodríguez-Sánchez, Kepa Amillano, Severina Domínguez Fernández, Maria Luque-Cabal, Idoia Morilla, Gemma Viñas, Javier Cortés, Begoña Martin-Castillo & Javier A. Menendez
dc.description.abstract
Background
Serum and urine metabolites have been investigated for their use as cancer biomarkers. The specificity of candidate metabolites can be limited by the impact of other disorders on metabolite levels. In particular, the increasing incidence of obesity could become a significant confounding factor.
Methods
Here we developed a multinomial classifier for the stratification of cancer, obesity and healthy phenotypes based on circulating glucose and formate levels. We quantified the classifier performance from the retrospective analysis of samples from breast cancer, lung cancer, obese individuals and healthy controls.
Results
We discovered that circulating formate levels are significantly lower in breast and lung cancer patients than in healthy controls. However, the performance of a cancer classifier based on formate levels alone is limited because obese patients also have low serum formate levels. By introducing a multinomial classifier based on circulating glucose and formate levels, we were able to improve the classifier performance, reaching a true positive rate of 79% with a false positive rate of 8%
Conclusions
Circulating formate is reduced in HER2+ breast cancer, non-small cell lung cancer and highly obese patients relative to healthy controls. Further studies are required to determine the relevance of these observations in other cancer types and diseases
dc.description.sponsorship
This work was supported by Cancer Research UK C596/A21140. We acknowledge
the Cancer Research UK Glasgow Centre (C596/A18076). This work was supported
also by grants from the Ministerio de Ciencia e Innovación, Plan Nacional de I+D
+I, Spain (Grant SAF2016-80639-P co-founded by the European Regional Development Fund [EU FEDER] to J. A. Menendez), and the Ministerio de Sanidad,
Servicios Sociales e Igualdad (EC10-125, Ayudas para el Fomento de la
Investigación Clínica Independiente to Begoña Martin-Castillo). JC and JJ also
acknowledge the support by the Fundació La Marató de TV3 (Catalonia, Spain)
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central (BMC)
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1186/s40170-019-0195-x
dc.relation.ispartof
Cancer and Metabolism, 2019, vol. 7, art. núm. 3
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Articles publicats (IdIBGi)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.subject
dc.title
Stratification of cancer and diabetes based on circulating levels of formate and glucose
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.type.peerreviewed
peer-reviewed