DUGiDocsCentral nicotine induces browning through hypothalamic κ opioid receptor
dc.contributor.author
dc.date.accessioned
2020-07-09T07:11:39Z
dc.date.available
2020-07-09T07:11:39Z
dc.date.issued
2019-09-06
dc.identifier.issn
2041-1723
dc.identifier.uri
dc.description.abstract
Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding and energy expenditure at the central level. Among the central actions of nicotine on body weight, much attention has been focused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue (WAT) is unclear. Here, we show that nicotine induces the browning of WAT through a central mechanism and that this effect is dependent on the κ opioid receptor (KOR), specifically in the lateral hypothalamic area (LHA). Consistent with these findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which correlates with smoking status. These data demonstrate that central nicotine-induced modulation of WAT browning may be a target against human obesity
dc.description.sponsorship
We would like to thank the technical support of IGC’s Advanced Imaging Facility (AIFUIC) and of Micron Oxford bioimaging unit. The research leading to these results has
received funding from the Xunta de Galicia (J.L.L.-G.: ED431C 2018/10; R.N.: 2015-
CP080 and 2016-PG057; M.L.: 2015-CP079 and 2016-PG068); Ministerio de Economía y
Competitividad (MINECO) co-funded by the FEDER Program of EU (J.L.L.-G.:
BFU2015–70523; R.N.: BFU2015–70664R; C.D.: BFU2017–87721-P; M.L.: RTI2018-
101840-B100; BFU2015–70454-REDT/Adipoplast and RTI2018–101840-B-I00); Instituto de Salud Carlos III (J.L.L.-G.: RD16/0011/0016; J.M.F.-R.: PI15–01934); European
Molecular Biology Organization (A.D.: EMBO-Installation Grant 3037); Human Frontier
Science Program (A.D.: HFSP-RGY0070/2016); Howard Hughes Medical Institute (A.D.:
HHMI-208576/Z/17/Z); US National Institutes of Health (K.R.: HL084207); American
Heart Association (K.R.: EIA#14EIA18860041); the University of Iowa Fraternal Order of
Eagles Diabetes Research Center (K.R.); Atresmedia Corporación (R.N. and M.L.: 2017-
PO004); Fundación BBVA (R.N.), European Foundation for the Study of Diabetes (R.N.);
and ERC Synergy Grant-2019-WATCH-810331 (R.N.). P.S.-C. is recipient of a fellowship from Xunta de Galicia (ED481B 2018/050). L.L.-P. is recipient of a fellowship from
Xunta de Galicia (ED481A-2016/094); E.R.-P. is recipient of a fellowship from MINECO
(BES-2015–072743). N.M.-S. is recipient of a fellowship from Xunta de Galicia (ED481B
2016/168–0) and from the European Union’s Horizon 2020 research and innovation
programme under the Marie Sklodowska-Curie actions. The CiMUS is supported by the
Xunta de Galicia (2016–2019, ED431G/05)
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Nature Research
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Reproducció digital del document publicat a: https://doi.org/10.1038/s41467-019-12004-z
dc.relation.ispartof
Nature Communications, 2019, vol. 10, art. núm. 4037
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Articles publicats (D-CM)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.title
Central nicotine induces browning through hypothalamic κ opioid receptor
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.type.peerreviewed
peer-reviewed