Circulating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosis
dc.contributor.author
dc.date.accessioned
2020-06-26T08:49:35Z
dc.date.available
2020-06-26T08:49:35Z
dc.date.issued
2019-09-17
dc.identifier.issn
2045-2322
dc.identifier.uri
dc.description.abstract
Evaluation of microRNAs (miRNAs) could allow characterization of the obstructive sleep apnea (OSA) and help diagnose it more accurately. We aimed to examine circulating miRNA profiles to establish the differences between non-OSA and OSA patients. Additionally, we aimed to analyse the effect of continuous positive airway pressure (CPAP) treatment on the miRNA profile. This observational, longitudinal study included 230 subjects referred to the Sleep Unit due to suspected OSA. Expression profiling of 188 miRNAs in plasma was performed in 27 subjects by TaqMan-Low-Density-Array. OSA-related miRNAs were selected for validation by RT-qPCR in 203 patients. Prediction models were built to discriminate between non-OSA and OSA: 1) NoSAS-score, 2) differentially expressed miRNAs, and 3) combination of NoSAS-score plus miRNAs. The differentially expressed miRNAs were measured after 6 months of follow-up. From the 14 miRNAs selected for validation, 6 were confirmed to be differentially expressed. The areas under the curve were 0.73 for the NoSAS-score, 0.81 for the miRNAs and 0.86 for the combination. After 6 months of CPAP treatment, miRNA levels in the OSA group seem to approximate to non-OSA levels. A cluster of miRNAs was identified to differentiate between non-OSA and OSA patients. CPAP treatment was associated with changes in the circulating miRNA profile
dc.description.sponsorship
Te
project is supported by PI 14/01266 and PI 18/00449 from the Instituto de Salud Carlos III (ISCIII), Fondo
Europeo de Desarrollo Regional (FEDER), Sociedad Espanola de Neumología y Cirugía Torácica (SEPAR)
and Societat Catalana de Pneumologia (SOCAP). Te work is supported by IRBLleida Biobank (B.0000682)
and PLATAFORMA BIOBANCOS PT17/0015/0027”. F.S.-M. is the recipient of a predoctoral fellowship from
“AGAUR-University of Lleida” and Convocatòria d’Ajuts 2018 de Promoció a la Recerca en Salut
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Nature Research
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1038/s41598-019-49940-1
dc.relation.ispartof
Scientific Reports, 2019, vol. 9, art. núm.13456
dc.relation.ispartofseries
Articles publicats (IdIBGi)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.subject
dc.title
Circulating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosis
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.type.peerreviewed
peer-reviewed