Exceptional human longevity is associated with a specific plasma phenotype of ether lipids
dc.contributor.author
dc.date.accessioned
2020-06-26T07:05:08Z
dc.date.available
2020-06-26T07:05:08Z
dc.date.issued
2019-02
dc.identifier.issn
2213-2317
dc.identifier.uri
dc.description.abstract
A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and ability to modulate oxidative stress. Our results demonstrate that a specific ether lipid signature can be obtained to define the centenarian state. This profile comprises higher level of alkyl forms derived from phosphatidylcholine with shorter number of carbon atoms and double bonds; and decreased content in alkenyl forms from phosphatidylethanolamine with longer chain length and higher double bonds. This compositional pattern suggests that ether lipids from centenarians are more resistant to lipid peroxidation, and that ether lipid signature expresses an optimized feature associated with exceptional human longevity. These results are in keeping with the free radical theory of aging
dc.description.sponsorship
We acknowledge funding from the Spanish Ministry of Education
and Science (ref. SAF2013–44663-R), and from the ‘Red Tematica de
Investigación Cooperativa en Envejecimiento y Fragilidad’ (RETICEF)
(ref. ISCIII2012-RED-43-029) to J.V.; and from the Spanish Ministry of
Economy and Competitiveness/Institute of Health Carlos III (ref. PI14/
00328), and the Autonomous Government of Catalonia, Department of
Health (ref. SLT002/16/00250) and Department of Business and
Knowledge (ref. 2017SGR696) to R.P. This study has been co-financed
by FEDER funds from the European Union (“Una manera de hacer
Europa”)
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1016/j.redox.2019.101127
dc.relation.ispartof
Redox Biology, 2019, vol. 21, art. núm. 101127
dc.relation.ispartofseries
Articles publicats (IdIBGi)
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri
dc.title
Exceptional human longevity is associated with a specific plasma phenotype of ether lipids
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.type.peerreviewed
peer-reviewed