Long-term impact of fecal transplantation in healthy volunteers
dc.contributor.author
dc.date.accessioned
2020-06-18T11:00:36Z
dc.date.available
2020-06-18T11:00:36Z
dc.date.issued
2019-12-30
dc.identifier.issn
1471-2180
dc.identifier.uri
dc.description.abstract
Fecal microbiota transplantation (FMT) has been recently approved by FDA for the treatment of refractory recurrent clostridial colitis (rCDI). Success of FTM in treatment of rCDI led to a number of studies investigating the effectiveness of its application in the other gastrointestinal diseases. However, in the majority of studies the effects of FMT were evaluated on the patients with initially altered microbiota. The aim of our study was to estimate effects of FMT on the gut microbiota composition in healthy volunteers and to monitor its long-term outcomes.
Results
We have performed a combined analysis of three healthy volunteers before and after capsule FMT by evaluating their general condition, adverse clinical effects, changes of basic laboratory parameters, and several immune markers. Intestinal microbiota samples were evaluated by 16S rRNA gene and shotgun sequencing. The data analysis demonstrated profound shift towards the donor microbiota taxonomic composition in all volunteers. Following FMT, all the volunteers exhibited gut colonization with donor gut bacteria and persistence of this effect for almost ∼1 year of observation. Transient changes of immune parameters were consistent with suppression of T-cell cytotoxicity. FMT was well tolerated with mild gastrointestinal adverse events, however, one volunteer developed a systemic inflammatory response syndrome.
Conclusions
The FMT leads to significant long-term changes of the gut microbiota in healthy volunteers with the shift towards donor microbiota composition and represents a relatively safe procedure to the recipients without long-term adverse events
dc.description.sponsorship
The CoDa data analysis was funded by Ministerio de Ciencia,
Innovación y Universidades (CODAMET, Ref.: RTI2018-095518-B-C21,2019-2021)
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
BMC
dc.relation
RTI2018-095518-B-C21
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1186/s12866-019-1689-y
dc.relation.ispartof
BMC Microbiology, 2019, vol. 19, art. núm. 312
dc.relation.ispartofseries
Articles publicats (D-IMA)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.subject
dc.title
Long-term impact of fecal transplantation in healthy volunteers
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.relation.projectID
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095518-B-C21/ES/METODOS DEL ANALISIS COMPOSICIONAL DE DATOS/
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
030647
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.FundingProgramme
dc.relation.ProjectAcronym