Lack of adverse effects in subchronic and chronic toxicity/ carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats
dc.contributor.author
dc.date.accessioned
2020-06-18T09:24:51Z
dc.date.available
2020-06-18T09:24:51Z
dc.date.issued
2019-02-12
dc.identifier.issn
0340-5761
dc.identifier.uri
dc.description
Hi ha una correcció d'aquest article publicat a Archives of Toxicology (2020) 94:1779–1781, disponible a https://doi.org/10.1007/s00204-020-02751-0
dc.description.abstract
In 2012, a controversial study on the long-term toxicity of a Roundup herbicide and the glyphosate-tolerant genetically modified (GM) maize NK603 was published. The EC-funded G-TwYST research consortium tested the potential subchronic and
chronic toxicity as well as the carcinogenicity of the glyphosate-resistant genetically modified maize NK603 by performing
two 90-day feeding trials, one with GM maize inclusion rates of 11 and 33% and one with inclusion rates of up to 50%, as
well as a 2-year feeding trial with inclusion rates of 11 and 33% in male and female Wistar Han RCC rats by taking into
account OECD Guidelines for the testing of chemicals and EFSA recommendations on the safety testing of whole-food/feed
in laboratory animals. In all three trials, the NK603 maize, untreated and treated once with Roundup during its cultivation,
and the conventional counterpart were tested. Differences between each test group and the control group were evaluated.
Equivalence was assessed by comparing the observed difference to differences between non-GM reference groups in previous studies. In case of significant differences, whether the effects were dose-related and/or accompanied by changes in
related parameters including histopathological findings was evaluated. It is concluded that no adverse effects related to the
feeding of the NK603 maize cultivated with or without Roundup for up to 2 years were observed. Based on the outcome of
the subchronic and combined chronic toxicity/carcinogenicity studies, recommendations on the scientific justification and
added value of long-term feeding trials in the GM plant risk assessment process are presented
dc.description.sponsorship
This study was carried out as part of the G-TwYST
project (“GM Plant Two Year Safety Testing”), financially supported
by the Seventh Framework Programme of the European Community
for Research, Technological Development and Demonstration Activities (FP7), Grant Agreement No. 632165
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1007/s00204-019-02400-1
dc.relation.ispartof
Archives of Toxicology, 2019, vol. 93, p. 1095-1139
dc.relation.ispartofseries
Articles publicats (D-EQATA)
dc.relation.uri
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.subject
dc.title
Lack of adverse effects in subchronic and chronic toxicity/ carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.relation.projectID
info:eu-repo/grantAgreement/EC/FP7/632165/EU/GMP Two Year Safety Testing/G-TWYST
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.type.peerreviewed
peer-reviewed
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
1432-0738