Survival, effect measures, and impact numbers after dementia diagnosis: a matched cohort study
dc.contributor.author
dc.date.accessioned
2020-06-15T11:31:45Z
dc.date.available
2020-06-15T11:31:45Z
dc.date.issued
2019-07-16
dc.identifier.issn
1179-1349
dc.identifier.uri
dc.description.abstract
Background: Knowledge on survival after diagnosis is important for all stakeholders. We
aimed to estimate the survival and life expectancy after a dementia diagnosis, and to quantify
the impact of dementia subtypes on mortality.
Methods: Retrospective matched cohort study using a linkage between a dementia-specific
registry and two primary care electronic medical records databases. Between 1 January 2007
and 31 December 2015 there were 5,156 subjects aged 60 years and over registered by the
Registry of Dementia of Girona and matched to 15,468 age-sex and comorbidity individuals
without dementia attended by general practitioners in the province of Girona (Catalonia,
Spain).
Results: The median survival was 5.2 years (95% CI 5.0 to 5.4), the median life expectancy
was 74.7 years (95% CI 71.9 to 76.5), and there were differences by gender. The mortality
rate was 127.1 per 1,000 person-years (95% CI 121.6 to 132.7), and the hazard ratio for
mortality in persons with dementia ranged between 1.63 (95% CI 1.52 to 1.76) for
Alzheimer’s disease and 2.52 (95% CI 1.90 to 3.35) for Parkinson-plus syndromes. There
was one death per year attributable to dementia for every 18.6 persons with dementia, and for
every 2.4 persons with dementia who die, one death was attributable to dementia.
Conclusion: The prognosis after dementia diagnosis is conditioned by demographic and
clinical features. Although survival is larger for women, they also experience a higher
number of years of life lost. Parkinson-plus syndromes and dementia due to multiple
etiologies are among the most malignant subtypes regarding mortality
dc.description.sponsorship
This study was supported by research grant PI05/01980
from the Spain’s Ministry of Science and Innovation
through the Carlos III Health Institute
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Dove Medical Press
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.2147/CLEP.S213228
dc.relation.ispartof
Clinical Epidemiology, 2019, vol. 11, p. 525-542
dc.relation.ispartofseries
Articles publicats (D-CM)
dc.rights
Attribution-NonCommercial 4.0 International
dc.rights.uri
dc.subject
dc.title
Survival, effect measures, and impact numbers after dementia diagnosis: a matched cohort study
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.type.peerreviewed
peer-reviewed