Epidemiology of dementia: prevalence and incidence estimates using validated electronic health records from primary care
dc.contributor.author
dc.date.accessioned
2020-06-15T11:04:40Z
dc.date.available
2020-06-15T11:04:40Z
dc.date.issued
2019-03-04
dc.identifier.issn
1179-1349
dc.identifier.uri
dc.description.abstract
Purpose: Updated estimates of incidence and prevalence of dementia are crucial to ensure
adequate public health policy. However, most of the epidemiological studies in the population
in Spain were conducted before 2010. This study assessed the validity of dementia diagnoses
recorded in electronic health records contained in a large primary-care database to determine
if they could be used for research purposes. Then, to update the epidemiology of dementia
in Catalonia (Spain), we estimated crude and standardized prevalence and incidence rates of
dementia in Catalonia in 2016.
Methods: The System for the Development of Research in Primary Care (SIDIAP) database
contains anonymized information for >80% of the Catalan population. Validity of dementia
codes in SIDIAP was assessed in patients at least 40 years old by asking general practitioners for
additional evidence to support the diagnosis. Crude and standardized incidence and prevalence
(95% CI) in people aged ≥65 years were estimated assuming a Poisson distribution.
Results: The positive predictive value of dementia diagnoses recorded in SIDIAP was estimated
as 91.0% (95% CI 87.5%–94.5%). Age- and sex-standardized incidence and prevalence of dementia were 8.6/1,000 person-years (95% CI 8.0–9.3) and 5.1% (95% CI 4.5%–5.7%), respectively.
Conclusion: SIDIAP contains valid dementia records. We observed incidence and prevalence
estimations similar to recent face-to-face studies conducted in Spain and higher than studies
using electronic health data from other European populations
dc.description.sponsorship
This work was supported by the Real world
Outcomes across the Alzheimer’s Disease spectrum for better
care: Multi-modal data Access Platform (ROADMAP) from
the Innovative Medicines Initiative (grant agreement 116020).
This project was also supported by clinical research grants
from Carlos III Health Institute, within the Net for Research
in Preventive Activities and Health Enhancement (RedIAPP
RD16/0007/0004) framework, and from the Agency for Management of University and Research Grants (2017 SGR 1146)
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Dove Medical Press
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.2147/CLEP.S186590
dc.relation.ispartof
Clinical Epidemiology, 2019, vol. 11, p. 217–228
dc.relation.ispartofseries
Articles publicats (D-CM)
dc.rights
Attribution-NonCommercial 4.0 International
dc.rights.uri
dc.subject
dc.title
Epidemiology of dementia: prevalence and incidence estimates using validated electronic health records from primary care
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
029705
dc.type.peerreviewed
peer-reviewed