Population-based multicase-control study in common tumors in Spain (MCC-Spain): Rationale and study design = Estudio multicaso-control de base poblacional de tumores comunes en España (MCC-Spain): razón y diseño del estudio

Castaño-Vinyals, Gemma
Aragonés, Nuria
Pérez-Gómez, Beatriz
Martín, Vicente
Llorca, Javier
Moreno, Victor
Altzibar, Jone-Miren
Ardanaz, Eva
García Tardón, Adonina
Alguacil, Juan
Peiró Pérez, Rosana
Navarro, Carmen
Pollán, Marina
Kogevinas, Manolis
Alonso, Maria Teresa
Amiano, Pilar
Arias, Cristina
Azpiri, Mikel
Benavente, Yolanda
Boldo, Elena
Bueno, Aurora
Bustamante, Mariona
Caballero, Francisco Javier
Campo Güerri, Elias
Cantón, Rafael
Capelo, Rocío
Casabonne, Delphine
Chirlaque, María Dolores
Cirac, Judith
Clofent, Juan
Colado, Enrique
Costas, Laura
Crous, Marta
Campo, Rosa del
Díaz Santos, Marian
Dierssen Sotos, Trinidad
Ederra, María
Espinosa, Ana
Fernández Cabrera, Marieta
Fernández Somoano, Ana
Fernández Villa, Tania
García Martín, Paloma
Gómez Acebo, Inés
González Puga, Cristina
Gràcia, Esther
Guevara, Marcela
Guinó, Elisabet
Huerta, José María
Lope, Virginia
López Abente, Gonzalo
López-Otín, Carlos
Merino Salas, Sergio
Mirón Pozo, Benito
Moreno, Eduardo
Moreno Iribas, Conchi
Olea, Nicolás
Osca Gelis, Gemma
Paré, L.
Porta, Miquel
Puig, Montse
Rivas del Fresno, Manuel
Robles, Claudia
Romero, Beatriz
Sáez Castillo, Ana Isabel
Sala i Serra, Maria
Salas Trejo, Dolores
Santaballa, Ana
Santibáñez, Miguel
Sierra, Ángeles
Souto, Ana
Villanueva, Cristina M.
Carrasco, E.
Sabaté, Y.
Persavento, C.
García, M.
Carrasco, G.
Expósito, A.
Andreu, M.
Bessa, X.
Piracés, M.
Lorente, J. A.
Tusquets, Ignasi
Collet, I.
Bory, F.
Pera, M.
Abella, E.
Garcia, F.
Salar, A.
Piñol, M.
Martín, M. V.
Garsot, E.
We present the protocol of a large population-based case-control study of 5 common tumorsin Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and pri-mary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer,1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chroniclymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age,sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) andfrom 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociode-mographic factors, environmental exposures, occupation, medication, lifestyle, and personal and familymedical history. In addition, participants completed a self-administered food-frequency questionnaireand telephone interviews. Blood samples were collected from 76% of participants while saliva sampleswere collected in CLL cases and participants refusing blood extractions. Clinical information was recordedfor cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals.Genotyping was done through an exome array enriched with genetic markers in specific pathways. Mul-tiple analyses are planned to assess the association of environmental, personal and genetic risk factorsfor each tumor and to identify pleiotropic effects.Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiol-ogy & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancersand will promote cancer research and prevention in Spain ​
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