This work was supported in part by the Spanish Instituto de Salud Carlos III
(ISCIII; FIS PI11/00692 and PI14/00329; to’ T. Puig), Fundacion Ramon Areces
(to T. Puig), the support of Catalonian Government (2017SGR00385), and La
Marató de TV3 (20131530, TPuig), financial support was from the University
of Girona (MPCUdG2016/036), and the University of Girona and La Caixa
Foundation awarded S. Palomeras with a predoctoral grant. A.D.-L. is funded
by a “Juan Rodés” contract (JR17/00016) from ISCIII. Ana B Crujeiras is funded
by a research contract “Miguel Servet” (CP17/00088) from the ISCIII