Automated sub-cortical brain structure segmentation combining spatial and deep convolutional features
dc.contributor.author
dc.date.accessioned
2019-09-20T10:51:59Z
dc.date.available
2019-09-20T10:51:59Z
dc.date.issued
2018-08-01
dc.identifier.issn
0213-9111
dc.identifier.uri
dc.description.abstract
Sub-cortical brain structure segmentation in Magnetic Resonance Images (MRI) has attracted the interest of the research community for a long time as morphological changes in these structures are related to different neurodegenerative disorders. However, manual segmentation of these structures can be tedious and prone to variability, highlighting the need for robust automated segmentation methods. In this paper, we present a novel convolutional neural network based approach for accurate segmentation of the sub-cortical brain structures that combines both convolutional and prior spatial features for improving the segmentation accuracy. In order to increase the accuracy of the automated segmentation, we propose to train the network using a restricted sample selection to force the network to learn the most difficult parts of the structures. We evaluate the accuracy of the proposed method on the public MICCAI 2012 challenge and IBSR 18 datasets, comparing it with different traditional and deep learning state-of-the-art methods. On the MICCAI 2012 dataset, our method shows an excellent performance comparable to the best participant strategy on the challenge, while performing significantly better than state-of-the-art techniques such as FreeSurfer and FIRST. On the IBSR 18 dataset, our method also exhibits a significant increase in the performance with respect to not only FreeSurfer and FIRST, but also comparable or better results than other recent deep learning approaches. Moreover, our experiments show that both the addition of the spatial priors and the restricted sampling strategy have a significant effect on the accuracy of the proposed method. In order to encourage the reproducibility and the use of the proposed method, a public version of our approach is available to download for the neuroimaging community
dc.description.sponsorship
Kaisar Kushibar and Jose Bernal hold FI-DGR2017 grant from the Catalan Government with reference numbers 2017FI_B00372 and 2017FI_B00476, respectively. This work has been partially supported by La Fundació la Marató de TV3, by Retos de Investigación TIN2014-55710-R, TIN2015-73563-JIN, and DPI2017-86696-R from the Ministerio de Ciencia y Tecnologia
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
info:eu-repo/grantAgreement/MINECO//TIN2014-55710-R/ES/HERRAMIENTAS DE NEUROIMAGEN PARA MEJORAR EL DIAGNOSIS Y EL SEGUIMIENTO CLINICO DE LOS PACIENTES CON ESCLEROSIS MULTIPLE/
info:eu-repo/grantAgreement/MINECO//TIN2015-73563-JIN/ES/SEGMENTACION AUTOMATICA DE LAS ESTRUCTURAS CEREBRALES PARA SU USO COMO BIOMARCADORES DE IMAGEN/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DPI2017-86696-R/ES/MODELOS PREDICTIVOS PARA LA ESCLEROSIS MULTIPE USANDO BIOMARCADORES DE RESONANCIA MAGNETICA DEL CEREBRO/
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1016/j.media.2018.06.006
dc.relation.ispartof
Medical Image Analysis, 2018, vol. 48, p. 177-186
dc.relation.ispartofseries
Articles publicats (D-ATC)
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri
dc.subject
dc.title
Automated sub-cortical brain structure segmentation combining spatial and deep convolutional features
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
029014
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.FundingProgramme
dc.relation.ProjectAcronym
dc.identifier.eissn
1578-1283