Evaluation of predictive value of CT imaging biomarkers in stroke patients after endovascular treatment

Abstract

Background: Ischemic stroke is a high incident disease in the world with a high morbi-mortality, that is why its management is in continuous development. During this development, radiological biomarkers have been studied to improve the early diagnosis to save as much cerebral tissue as is possible. When the diagnosis of stroke is performed it can be treated pharmacological (with rtPA) or surgical (mechanical thrombectomy) depending on time of stroke onset, but the outcome of this treatment is uncertain. Nowadays biomarkers are focus on the diagnosis but not in the prognosis after the treatment and maybe the outcome can be worst if the thrombus is removed or it cannot be clinical improve. This prognosis biomarkers are needed in order to select properly the patients which can be benefited with treatment, to the proper use of medical resources and to provided based on information to the family for a better chose of their familiar treatment. Objective: The aim of this project is to analyze that biomarkers which can allow us to predict the outcome of a stroke patient treated with mechanical thrombectomy. Design: A multicentric observational prospective cohort project. Seven third level hospitals (three from Catalonia, two from Madrid and two from Valencia) will participate in this project. Participants: Patients older than eighteen years old with a stroke treated with mechanical thrombectomy and with all the data collected. Methods: We will record clinical with a data collection form where all the clinical variables are written. The radiological variables will be obtained from the first CT performed for the diagnosis and will be interpreted by two different neuroradiologist from the investigation team