BACKGROUND
Cervical cancer is the third neoplasia among worldwide. It is known, that cervical carcinogenesis is
based on the persistence of HPV infection. Fortunately, screening protocols have been recently
applied. Those protocols showed great results reducing invasive cancers and offering less invasive
techniques due to early detection. The screening with cytology should be performed to women between
25 and 30 years, every 3 years. It’s done by HPV tests every 5 years in women between 35 and 60
years old. Treating precancerous injuries is effective, although, the number of women treated is
increasing. The main techniques applied to find out precancerous lesions such us L-SIL and H-SIL are
cytology, colposcopy and HPV detection. The main technique to treat them is the conization (LEEP
procedure). Once a precancerous lesion is confirmed a resection procedure must be done to avoid the
progression of the lesion. After that, if the histological margins aren’t affected the patient should be
followed-up among 20 years. But if the results show affected margins, either the patient can be
followed-up or the conization can be repeated.
OBJECTIVE
The aim of this study is to compare the local recurrence between follow-up procedures and re-
conization, in women with positive exocervical margins after conization (either for HSIL or LSIL).
STUDY DESING AND POPULATION
A randomized controlled clinical trial will be done. It will be a multicentric study performed on the
Province of Girona between the 2019 and 2023. The sample size will be of 144 patients who meet
inclusion criteria.
METHODS
The main variables will be: local recurrence confirmed by histology and following-up or re-conization.
The following covariables will be considered: age, gravidity, tobacco, alcohol, IMC, HPV, HPV
vaccination, STD and number of sexual partners. The patients with LSIL will be classified in two groups
randomly: the follow-up group and the re-conization group. The same distribution will be applied for the
HSIL patients. Those patients will be followed-up for two years and the local recurrence will be analysed
and compared in the two different groups
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