Role of Peguero Lo-Presti criteria in the differential diagnosis between hypertrophic cardiomyopathy and hypertensive heart disease

Abstract

BACKGROUND: Electrocardiogram is an easy tool to determinate left ventricular hypertrophy, but classical criteria have a low sensitivity. A new ECG criteria, Peguero-Lo Presti has demonstrated in patients with Hypertensive Heart Disease (HHD) that it is more sensible. Hypertrophic Cardiomyopathy (HCM) is characterized by an heterogenous clinical and phenotypic expression that it is responsible of the mayor number of deaths in young people due to its arrhythmogenic capacity and sudden cardiac death. Moreover, more of patients are asymptomatic in early phases of the disease which makes very necessary to determinate a very sensible marker of this disease to make an early diagnosis and avoid these fatal consequences.

HYPOTHESES: Peguero-Lo Presti criteria is more sensible to detect HCM than Sokolow- Lyon voltage index. Moreover, due to the different hypertrophic pattern in HHD (concentric

and symmetrical hypertrophy) and HCM (asymmetrical septal hypertrophy), Peguero-Lo Presti criteria could have a different expression reflected on the 12-lead ECG. OBJECTIVES: The main of this study is to determinate the sensitivity of Peguero-Lo Presti criteria in patients with HCM and evaluate the role of this criteria in the differential diagnosis between HHD and HCM. METHODS: A prospective analytic and observational case-control study will be designed. The case-group will be formed by 185 patients with HCM and the control-group will be formed by 185 patients with HHD. This study will be developed at Josep Trueta Hospital in Girona for the Cardiology Department for 2 years