Rapid Discrimination of multiple myeloma patients by artificial neural networks coupled with mass spectrometry of peripheral blood plasma
dc.contributor.author
dc.date.accessioned
2019-06-12T08:50:16Z
dc.date.available
2019-06-12T08:50:16Z
dc.date.issued
2019-05-28
dc.identifier.issn
2045-2322
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dc.description.abstract
Multiple myeloma (MM) is a highly heterogeneous disease of malignant plasma cells. Diagnosis and monitoring of MM patients is based on bone marrow biopsies and detection of abnormal immunoglobulin in serum and/or urine. However, biopsies have a single-site bias; thus, new diagnostic tests and early detection strategies are needed. Matrix-Assisted Laser Desorption/Ionization Time-of Flight Mass Spectrometry (MALDI-TOF MS) is a powerful method that found its applications in clinical diagnostics. Artificial intelligence approaches, such as Artificial Neural Networks (ANNs), can handle non-linear data and provide prediction and classification of variables in multidimensional datasets. In this study, we used MALDI-TOF MS to acquire low mass profiles of peripheral blood plasma obtained from MM patients and healthy donors. Informative patterns in mass spectra served as inputs for ANN that specifically predicted MM samples with high sensitivity (100%), specificity (95%) and accuracy (98%). Thus, mass spectrometry coupled with ANN can provide a minimally invasive approach for MM diagnostics
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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Reproducció digital del document publicat a: https://doi.org/10.1038/s41598-019-44215-1
dc.relation.ispartof
Scientific Reports, 2019, vol. 9, núm. 1, p. Art.num.7975
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Articles publicats (D-CM)
dc.rights
Reconeixement 4.0 Internacional
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dc.source
Deulofeu, Meritxell Kolářová, Lenka Salvadó Martín, Victòria Peña-Méndez, Eladia María Almá i, Martina tork, Martin Pour, Luděk Boadas Vaello, Pere evčíková, Sabina Havel, Josef Vaňhara, Petr 2019 Rapid Discrimination of multiple myeloma patients by artificial neural networks coupled with mass spectrometry of peripheral blood plasma Scientific Reports 9 1 Art.num.7975
dc.subject
dc.title
Rapid Discrimination of multiple myeloma patients by artificial neural networks coupled with mass spectrometry of peripheral blood plasma
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
029936
dc.type.peerreviewed
peer-reviewed