Validation of sentinel lymph node biopsy in early stages of oropharyngeal cancer
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dc.date.accessioned
2019-06-11T10:43:14Z
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2019-06-11T10:43:14Z
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2019-01
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Background: Over the years the approach to cervical lymph node metastasis in
oropharyngeal cancer has evolved to a more conservative form. The controversy
arises in cases where it is not possible to detect cervical lymph node metastasis by
means of clinical or imaging techniques. In these cases, elective neck dissection is
traditionally recommended when the tumor size and subsite confers at least a 20%
risk of lymphatic spread. This implies that a high percentage is submitted to a
surgical procedure without need. Therefore, elective neck dissection is the current
treatment and gold standard for neck staging. The sentinel lymph node biopsy is a
promising technique that its application in clinical practice could imply the saving
of an unnecessary surgical intervention. In the same way that it could play an
important role in lymphatic staging as well as in prognosis, since lymphatic
involvement is the main risk factor for decreased survival.
Obejective: The main objective is, on one hand, to determine the sensitivity,
specificity and negative predictive value for sentinel lymph node biopsy validation
and, on the other hand, to determine the recurrences and survival in the same
group of patients in order to reinforce the validity of the sentinel lymph node.
Methods: A cross-sectional study will be conducted to establish the diagnostic
test validation. A sample of 32 subjects selected in a consecutive non-probability
manner will be analyzed.
Once the lymphatic staging has been performed, the sample will be included in a
secondary study. A longitudinal study will be carried out dividing the sample
between two groups depending on the lymph node involvement. These two
groups will be followed to evaluate local and regional recurrences at 2 years, as
well as survival at 5 years. We will use Cox regression for the multivariate analysis
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application/pdf
dc.language.iso
eng
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Medicina (TFG)
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.title
Validation of sentinel lymph node biopsy in early stages of oropharyngeal cancer
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info:eu-repo/semantics/bachelorThesis
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info:eu-repo/semantics/openAccess
dc.audience.educationlevel
Estudis de grau