Theoretical study of the hydroxylation of phenols mediated by an end-on bound superoxo copper(II) complex
dc.contributor.author
dc.date.accessioned
2019-05-06T10:01:31Z
dc.date.available
2019-05-06T10:01:31Z
dc.date.issued
2009-02
dc.identifier.issn
0949-8257
dc.identifier.uri
dc.description.abstract
Peptidylglycine α-amidating monooxygenase and dopamine β-monooxygenase are copper-containing proteins which catalyze essential hydroxylation reactions in biological systems. There are several possible mechanisms for the reductive O2-activation at their mononuclear copper active site. Recently, Karlin and coworkers reported on the reactivity of a copper(II)–superoxo complex which is capable of inducing the hydroxylation of phenols with incorporated oxygen atoms derived from the Cu(II)-O2 ·− moiety. In the present work the reaction mechanism for the abovementioned superoxo complex with phenols is studied. The pathways found are analyzed with the aim of providing some insight into the nature of the chemical and biological copper-promoted oxidative processes with 1:1 Cu(I)/O2-derived species
dc.description.sponsorship
Financial help has been furnished by the Spanish Ministerio de Educación y
Ciencia (MEC) projects No. CTQ2005-08797-C02-01/BQU and CTQ2008-03077/BQU and by the Catalan Department d’Universitats, Recerca i Societat de la Informació (DURSI) of the Generalitat de Catalunya project No. 2005SGR-00238
dc.format.extent
13 p.
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Springer-Verlag
dc.relation
MEC/PN 2005-2008/CTQ2005-08797-C02-01
info:eu-repo/grantAgreement/MICINN//CTQ2008-03077/ES/CLUSTERES METALICOS Y SEMIMETALICOS. ESTUDIOS DE AROMATICIDAD Y REACTIVIDAD/
dc.relation.isformatof
Versió postprint del document publicat a: https://doi.org/10.1007/s00775-008-0447-7
dc.relation.ispartof
© Journal of Biological Inorganic Chemistry, 2009, vol. 14, núm. 2, p. 273-285
dc.relation.ispartofseries
Articles publicats (D-Q)
dc.rights
Tots els drets reservats
dc.source
Güell Serra, Mireia Luis Luis, Josep Maria Siegbahn, P. E. M. Solà i Puig, Miquel 2009 Theoretical study of the hydroxylation of phenols mediated by an end-on bound superoxo copper(II) complex Journal of Biological Inorganic Chemistry 14 2 273 285
dc.title
Theoretical study of the hydroxylation of phenols mediated by an end-on bound superoxo copper(II) complex
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.identifier.idgrec
010576
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
dc.relation.ProjectAcronym
dc.identifier.eissn
1432-1327