Fungal treatment of metoprolol and its recalcitrant metabolite metoprolol acid in hospital wastewater: Biotransformation, sorption and ecotoxicological impact
dc.contributor.author
dc.date.accessioned
2019-03-13T11:11:33Z
dc.date.available
2019-03-13T11:11:33Z
dc.date.issued
2019-04-01
dc.identifier.issn
0043-1354
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dc.description.abstract
Hospital wastewater (HWW) effluents represent an important source of contaminants such as pharmaceutical compounds and their human metabolites. To better evaluate dedicated treatment of hospital effluents for pollutant mitigation, not only the parent compounds should be considered but also the intermediates generated during treatment. The metabolite metoprolol acid (MTPA) has been found in urban wastewaters at higher concentration than its parent compound metoprolol (MTP), being more recalcitrant to biodegradation. The aim of this study was to investigate degradation, transformation and sorption of the β-blocker MTP, and its recalcitrant metabolite MTPA, during water treatment based on the fungi Ganoderma lucidum, Trametes versicolor and Pleurotus ostreatus. Fourteen intermediates were identified in MTP biotransformation while five of them also attributed to MTPA biodegradation and two to MTPA only. Their identification allowed their correlation in separate biotransformation pathways suggested. The highest degradation rate of metoprolol (up to 51%) and metoprolol acid (almost 77%) was found after 15-days treatment with Ganoderma lucidum, with an increase in toxicity up to 29% and 4%, respectively. This fungus was further selected for treating real HWW in a batch fluidized bed bioreactor (FBB). Treated wastewater and fungal biomass samples were used to evaluate the distribution of the target compounds and the intermediates identified between solid and liquid phases. While similar elimination capabilities were observed for the removal of metoprolol, and even higher for its persistent metabolite metoprolol acid, the extent on compound transformation diminished considerably compared with the study treating purified water: a high level of the persistent α-HMTP and TP240 were still present in effluent samples (15% and 6%, respectively), being both TPs present at high proportion (up to 28%) in fungal biomass. This is the first time that pharmaceutical TPs have been investigated in the fungal biomass
dc.description.sponsorship
This work was supported funded by the Spanish Ministry ofEconomy and Competitiveness (CTM2013-48548-C2), partly fun-ded by the European Union through the European RegionalDevelopment Fund (ERDF) and supported by the Generalitat deCatalunya (Consolidate Research Group 2017 SGR 14, 2017 SGR1404 and ICRA-ENV 2017 SGR 1124). The Department of Chemical,Biological and Environmental Engineering of the UniversitatAut onoma de Barcelona is a member of the Xarxa de Refer encia enBiotecnologia de la Generalitat de Catalunya. A. Ja en-Gil acknowl-edges his PhD scholarship from AGAUR (2018FI_B1_00212), F.Castellet-Rovira acknowledges a predoctoral grant from UAB and S.Rodriguez-Mozaz acknowledges the Ramon y Cajal program (RYC-2014-16707). We would like to thank Sant Joan de D eu Hospitalstaff for their collaboration during the sampling campaign
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.relation
MINECO/PN 2013-2016/CTM2013-48545-C2-2-R
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Versió postprint del document publicat a: https://doi.org/10.1016/j.watres.2018.12.054
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© Water Research, 2019, vol. 152, p. 171-180
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Articles publicats (ICRA)
dc.rights
Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
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dc.subject
dc.title
Fungal treatment of metoprolol and its recalcitrant metabolite metoprolol acid in hospital wastewater: Biotransformation, sorption and ecotoxicological impact
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.date.embargoEndDate
info:eu-repo/date/embargoEnd/2021-04-01
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed