Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients
dc.contributor.author
dc.date.accessioned
2019-01-30T07:46:02Z
dc.date.available
2019-01-30T07:46:02Z
dc.date.issued
2018-07-18
dc.identifier.uri
dc.description.abstract
Patients with end-stage renal disease have very high mortality. In individuals on hemodialysis,
cardiovascular deaths account for ~50% of all deaths in this population, mostly due to
arrhythmia. To determine the causes of these arrhythmic deaths is essential in order to
adopt preventive strategies. The main objective of this study was to investigate whether, the
presence of QTc interval alterations, from electrolyte abnormalities or presence of rare
genetic variants, could have a relationship with sudden arrhythmogenic deaths in end-stage
renal disease patients.
Methods
We recorded the pre- and post-dialysis QTc interval in 111 patients undergoing hemodialysis.
In 47 of them, we analyzed 24 SCD-related genes including the most prevalent genes
associated with long QT syndrome using a custom resequencing panel.
Results
We found a positive although not significant association between the presence of long QTc
and mortality in a subset of end-stage renal disease patients. In addition, in five patients with
long QTc only after dialysis (21.7%) we detected rare potentially pathogenic genetic variants.
Three out of these five carriers subsequently died suddenly.
Conclusions
Genetic background may be determinant in the risk of sudden cardiac death in these
patients. We recommend evaluating the QTc interval before and after hemodialysis, and
performing a genetic analysis of individuals with long QTc after hemodialysis
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science (PLoS)
dc.relation.isformatof
Reproducció digital del document publicat a: https://doi.org/10.1371/journal. pone.0200756
dc.relation.ispartof
PLoS ONE, 2018, vol.13, núm. 7, p. e0200756
dc.relation.ispartofseries
Articles publicats (IdIBGi)
dc.rights
Attribution 4.0 International
dc.rights.uri
dc.title
Role of genetic and electrolyte abnormalities in prolonged QTc interval and sudden cardiac death in end-stage renal disease patients
dc.type
info:eu-repo/semantics/article
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.identifier.idgrec
028884
dc.type.peerreviewed
peer-reviewed
dc.identifier.eissn
1932-6203