Antitumor Ribonucleases
dc.contributor.author
dc.date.accessioned
2019-01-11T07:26:28Z
dc.date.available
2019-01-11T07:26:28Z
dc.date.issued
2011-07-12
dc.identifier.isbn
978-3-642-21077-8
dc.identifier.uri
dc.description.abstract
Ribonucleases are small basic proteins that have shown remarkable antitumor activity linked to their ability to destroy RNA. Therefore, they are a second line of cancer chemotherapeutics as they are not genotoxic. This chapter summarizes the main biochemical characteristics of these enzymes and the key factors responsible for their cytotoxic mechanism. Some of them are shared by most cytotoxins, but each RNase has particular cancer cell killing abilities. The effects on the cell cycle and the induced apoptosis mechanism are cell dependent. The knowledge obtained from the cytotoxic mechanism of natural cytotoxic RNases has been used to artificially engineer more potent and selective RNA-degrading enzymes. These approaches are also described. The chapter ends with a brief description of the results of the clinical trials performed with RNases
dc.description.sponsorship
This work has been supported by grants BFU2009-06935 from MICINN (Spain) and GRCT04 from the University of Girona
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.relation
info:eu-repo/grantAgreement/MICINN//BFU2009-06935/ES/Bases Moleculares Del Plegamiento Y Citotoxicidad De Las Ribonucleasas Pancreaticas. Evaluacion De La Actividad Citotoxica Y Diseño De Estrategias Para Su Control Mediante Splicing Proteico./
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Versió postprint del capítol 3 del llibre publicat a https://doi.org/10.1007/978-3-642-21078-5_3
dc.relation.ispartof
Nicholson, Allen W.(eds). Ribonucleases. (Nucleic Acids and Molecular Biology, núm. 26). DOI https://doi.org/10.1007/978-3-642-21078-5, p.55-88
dc.relation.ispartofseries
Llibres / Capítols de LLibre (D-B)
dc.rights
Tots els drets reservats
dc.subject
dc.title
Antitumor Ribonucleases
dc.type
info:eu-repo/semantics/bookPart
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/acceptedVersion
dc.identifier.doi
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed
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dc.identifier.eisbn
978-3-642-21078-5