Approaches to Endow Ribonucleases with Antitumor Activity: Lessons Learned from the Native Cytotoxic Ribonucleases
dc.contributor.author
dc.date.accessioned
2019-01-08T16:00:46Z
dc.date.available
2019-01-08T16:00:46Z
dc.date.issued
2016
dc.identifier.isbn
978-953-51-2813-7
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dc.description.abstract
Typical antitumor drugs disrupt the flow of biochemical information from DNA to
proteins with the aim of precluding uncontrolled cell proliferation and inducing cancer
cell apoptosis. However, most of the currently used small antitumor drugs are genotoxic
because they act over DNA. Pharmaceutical industry is now searching for a new line of
cancer chemotherapeutics without genotoxic effectsǯ Ribonucleases (RNases) are small
basic proteins, present in all life forms, which belong to this kind of chemotherapeutics.
Some of them present with remarkable selective antitumor activity linked to their ability
to destroy RNA, a powerful way to control gene expression, leaving DNA unharmed.
In the last two decades, the knowledge gained on the cytotoxic mechanism of these
RNases has been used to engineer more powerful and selective variants to kill cancer
cells. In this chapter, we describe the advances reached in endowing an RNase with
antitumor abilities
dc.description.sponsorship
This work is supported by grants BIO2013‐435217 from Ministerio de Economia y Competiti‐
vidad (MINECO), Spain; SGR2014‐70 from Generalitat de Catalunya, Spain; and
MPCUdG2016‐18 from Universitat de Girona
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
InTech
dc.relation
MINECO/PN 2013-2016/BIO2013-435217
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Reproducció digital del document publicat a: https://doi.org/10.5772/65730
dc.relation.ispartof
Bankovic, Jasna (eds.). Anti-cancer Drugs - Nature, Synthesis and Cell, 2016, p, 135-168
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Llibres / Capítols de LLibre (D-B)
dc.rights
Attribution 4.0 International
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dc.subject
dc.title
Approaches to Endow Ribonucleases with Antitumor Activity: Lessons Learned from the Native Cytotoxic Ribonucleases
dc.type
info:eu-repo/semantics/bookPart
dc.rights.accessRights
info:eu-repo/semantics/openAccess
dc.type.version
info:eu-repo/semantics/publishedVersion
dc.identifier.doi
dc.contributor.funder
dc.type.peerreviewed
peer-reviewed